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Merck
CN

33746

Moxidectin

VETRANAL®, analytical standard

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About This Item

Empirical Formula (Hill Notation):
C37H53NO8
CAS Number:
113507-06-5
Molecular Weight:
639.82
NACRES:
NA.24
PubChem Substance ID:
329754646
UNSPSC Code:
41116107
MDL number:
MFCD00866560

Key Documents

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Product Name

Moxidectin, VETRANAL®, analytical standard

InChI

1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

SMILES string

CO\N=C1/C[C@]2(C[C@@H]3CC(C\C=C(C)\C[C@@H](C)\C=C\C=C4/COC5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@@H]([C@H]1C)\C(C)=C\C(C)C

InChI key

YZBLFMPOMVTDJY-LSGXYNIPSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

−20°C

Quality Level

100

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Application

Moxidectin may be used as a reference standard in the determination of moxidectin residues in liver samples using high-performance liquid chromatography coupled with a fluorescence detector (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Chemical structure: ß-lactam
Moxidectin is a semisynthetic milbemycin derivative of nemadectin, which is used as an anthelmintic drug.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

hcodes

H301,H400

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2874
BCCL1214
BCCH5455
BCCD9715
BCCB2810

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Kirk's Current Veterinary Therapy XIV (2013)
Multiresidue method for the determination of avermectin and moxidectin residues in the liver using HPLC with fluorescence detection.
Roudaut B.
Analyst, 123(12), 2541-2544 (1998)
Sheep Flock Health: A Planned Approach (2009)
Multiple anthelmintic resistance of Haemonchus contortus, including a case of moxidectin resistance, in a Dutch sheep flock.
R Van den Brom et al.
The Veterinary record, 173(22), 552-552 (2013-11-08)
Esra Yilmaz et al.
Experimental parasitology, 200, 61-66 (2019-04-05)
Anthelmintic and in particular macrocyclic lactone (ML) resistance is a widespread problem in trichostrongyloid parasitic nematodes, yet mechanisms of ML resistance are still poorly understood. In the absence of target-site changes in resistant parasite field populations, increased drug extrusion and
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Protocols

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