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32937

Supelco

Ochratoxin A

from Aspergillus ochraceus, reference material

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Synonym(s):
N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
Empirical Formula (Hill Notation):
C20H18ClNO6
CAS Number:
303-47-9
Molecular Weight:
403.81
Beilstein:
1301486
EC Number:
206-143-7
MDL number:
MFCD00078079
UNSPSC Code:
85151701
PubChem Substance ID:
329754398

biological source

Aspergillus ochraceus

grade

analytical standard
reference material

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

−20°C

SMILES string

C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O

InChI

1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1

InChI key

RWQKHEORZBHNRI-BMIGLBTASA-N

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General description

Ochratoxin A, a mycotoxin, is a naturally occurring secondary metabolite, produced by filamentous fungi, such as Aspergillus and Penicillium. It has been classified as a group 2B substance by International Agency for Research on Cancer, for possibly being carcinogenic to humans

Application

The CRM can also be used as follows:
  • Identification and determination of ochratoxin A in different types of commercial coffee samples using dispersive liquid-liquid microextraction-solidification of a floating organic drop (DLLME-SFO) for sample treatment and ultra high-performance liquid chromatography-positive electrospray ionization-tandem mass spectrometry (UHPLC-(+-ESI)-MS/MS)
  • Determination of ochratoxin A in beer samples by a selective method based on salting-out assisted liquid-liquid extraction (SALLE) and ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
  • Simultaneous determination of ochratoxin A and ochratoxin B in Tokaj wine samples using online solid phase extraction (SPE) combined with high-performance liquid chromatography-fluorescence detection(HPLC-FD)
  • Development of an online-SPE-HPLC method to determine ochratoxin A in wine samples
  • Electrochemical determination of ochratoxin A using an aptamer-based on functionalized graphene (f-graphene) doped chitosan in grape juice samples by differential pulse voltammetry

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H300,H351

Precautionary Statements

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

高风险级别生物产品--毒素类产品
危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reversed-phase liquid chromatographic method for the determination of ochratoxin A in wine.
Dall?Asta C, et al.
Journal of Chromatography A, 1024(1-2), 275-279 (2004)
Determination of ochratoxin A in beer marketed in Spain by liquid chromatography with fluorescence detection using lead hydroxyacetate as a clean-up agent.
Medina A, et al.
Journal of Chromatography A, 1083(1-2), 7-13 (2005)
Zheng Han et al.
Journal of chromatography. A, 1217(26), 4365-4374 (2010-05-21)
The paper reported a reliable analytical method for simultaneous determination of ochratoxin A (OTA) and ochratoxin B (OTB) in traditional Chinese medicines (TCMs) by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The development of the method and investigations on the matrix
Abdelhamid Abbas et al.
International journal of food microbiology, 161(3), 172-181 (2013-01-22)
The ochratoxin A (OTA) polyketide synthase otapks gene has been cloned from Penicillium verrucosum. A P. verrucosum mutant in which the otapksPV gene has been interrupted cannot synthesize ochratoxin A. The protein is most similar to the citrinin polyketide synthase
Xia Geng et al.
Analytical and bioanalytical chemistry, 405(8), 2443-2449 (2013-01-31)
By taking advantage of the intrinsic fluorescence of ochratoxin A (OTA), we present a fluorescence anisotropy approach for rapid analysis of the interactions between OTA and aptamers. The specific binding of OTA with a 36-mer aptamer can induce increased fluorescence
View All Related Papers

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