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Carazolol-d7

VETRANAL®, analytical standard

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Synonym(s):
1-(Carbazol-4-yloxy)-3-(isopropyl-d7-amino)-2-propanol, 4-(2-Hydroxy-3-isopropyl-d7-amino-propoxy)carbazole
Empirical Formula (Hill Notation):
C18D7H15N2O2
CAS Number:
1173021-02-7
Molecular Weight:
305.42
MDL number:
MFCD16652536
UNSPSC Code:
41116107
PubChem Substance ID:
329754338
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

mass shift

M+7

SMILES string

[2H]C([2H])([2H])C([2H])(NCC(O)COc1cccc2[nH]c3ccccc3c12)C([2H])([2H])[2H]

InChI

1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3/i1D3,2D3,12D

InChI key

BQXQGZPYHWWCEB-QLWPOVNFSA-N

General description

Carazolol-d7 is an isotopically labeled compound of the β-blocker, carazolol.

Application

Carazolol-d7 may be used as an internal standard for the determination of carazolol in animal tissues and water samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and ultra-fast liquid chromatography-quadrupole/linear ion trap mass spectrometry (UFLC-Q/TRAP MS), respectively.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Kaufmann et al.
Rapid communications in mass spectrometry : RCM, 15(18), 1747-1751 (2001-09-14)
A fast and simple method for the quantification of a number of tranquilizers and the beta-blocker Carazolol in pork and bovine kidney is described. Extracts are purified/concentrated by a solid phase extraction step and separated on a reversed phase column
Simultaneous determination of nine beta-blockers in porcine tissues by ultra-fast liquid chromatography coupled with quadrupole/linear ion trap mass spectrometry.
Zhang H, et al.
Se Pu / Chinese Journal of Chromatography, 32(6), 573-581 (2014)
Validating the rejection of trace organic chemicals by reverse osmosis membranes using a pilot-scale system.
Fujioka T, et al.
Desalination, 358, 18-26 (2015)
Jian-Qiao Cheng et al.
Molecules (Basel, Switzerland), 24(4) (2019-03-03)
This paper presents an application of high performance liquid chromatography coupled with quadrupole orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the analysis of 27 β-blockers and metabolites in milk powder. Homogenized milk power samples were extracted by acetonitrile and purified
Lenise Guimarães de Oliveira et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(1), 32-39 (2016-11-22)
A method for the determination of five sedatives and 14 β-blocker residues in swine, bovine and equine kidney was validated. Samples were extracted with acetonitrile and purified using dispersive solid phase extraction (d-SPE) with Celite 545 with subsequent analysis by

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