32442
Amitraz Metabolite BTS 27271
PESTANAL®, analytical standard
Synonym(s):
N-(2,4-Dimethylphenyl)-N′-methylformamidine, N-Methyl-N′-2,4-xylylformamidine
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About This Item
Empirical Formula (Hill Notation):
C10H14N2
CAS Number:
Molecular Weight:
162.23
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
1210087
MDL number:
InChI key
VXSNJXDZTGFDMB-UHFFFAOYSA-N
SMILES string
CN\C=N\c1ccc(C)cc1C
InChI
1S/C10H14N2.ClH/c1-8-4-5-10(9(2)6-8)12-7-11-3;/h4-7H,1-3H3,(H,11,12);1H
grade
analytical standard
product line
PESTANAL®
application(s)
agriculture
environmental
Legal Information
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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M A Pass et al.
Journal of veterinary pharmacology and therapeutics, 18(3), 210-215 (1995-06-01)
Amitraz and its active metabolite BTS27271 were given intravenously to ponies and sheep at equimolar doses of 1 mg/kg and 0.68 mg/kg, respectively, and the plasma concentrations of amitraz and BTS27271 estimated at various times thereafter. Amitraz was hydrolysed to
T H Chen et al.
The Journal of pharmacology and experimental therapeutics, 271(3), 1240-1245 (1994-12-01)
We tested the hypothesis that the formamidine pesticide amitraz and its metabolites inhibit insulin release from a rat beta-cell line (RINm5F) by decreasing intracellular cyclic AMP levels and examined whether GTP-binding proteins were involved in the process. Amitraz and its
A F Lehner et al.
Journal of analytical toxicology, 28(7), 553-562 (2004-11-02)
Amitraz (N'-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methyl-methanimidamide) is an alpha-2 adrenergic agonist used in veterinary medicine primarily as a scabicide- or acaricide-type insecticide. As an alpha-2 adrenergic agonist, it also has sedative/tranquilizing properties and is, therefore, listed as an Association of Racing Commissioners International Class
Carmen Ferrer et al.
Journal of AOAC International, 93(2), 380-388 (2010-05-20)
This paper compares the performance of the three most widely employed multiresidue methods [quick, easy, cheap, effective, rugged, and safe (QuEChERS), mini-Luke, and ethyl acetate] currently used for the determination of amitraz residues in fruits. A fast and differentiated analysis
M A Pass et al.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 99(1-2), 169-172 (1991-01-01)
1. Amitraz was rapidly metabolised to BTS27271 after intravenous administration to sheep. 2. Amitraz and BTS27271 had significant H1-histamine antagonist activity on isolated guinea-pig ileum. BTS27271 was approximately 3.3 times as potent as amitraz. 3. Intravenous injection of amitraz and
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