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32161

Supelco

Gamithromycin

VETRANAL®, analytical standard

Synonym(s):

(2R,3S,4R,5S,8RR,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylohexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one

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About This Item

Empirical Formula (Hill Notation):
C40H76N2O12
CAS Number:
145435-72-9
Molecular Weight:
777.04
UNSPSC Code:
41116107
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

InChI

1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25?,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1

InChI key

VWAMTBXLZPEDQO-FWEXOAGLSA-N

Related Categories

General description

Gamithromycin is a drug, which is administered to cattle for the treatment of bovine respiratory disease caused by Pasteurella multocida, Histophilus somni and Mannheimia haemolytica. It is also effective in treating certain infections caused by Mycoplasma.

Application

Gamithromycin may be used as a reference standard in the determination of gamithromycin in samples of plasma, lung tissue and pulmonary epithelial lining fluid using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H361d

Hazard Classifications

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL2200
BCCG3892
BCCG2236
BCCB8747
BCCB3538

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Michael Kellermann et al.
Research in veterinary science, 97(2), 199-203 (2014-09-23)
This study assessed the plasma kinetics and skin/plasma concentration ratio of the azalide antibiotic gamithromycin (ZACTRAN(®), Merial) in sheep after a single subcutaneous administration at 6 mg/kg bodyweight. Gamithromycin concentrations in plasma samples collected at various intervals up to 21
Jase J Ball et al.
Journal of animal science, 96(3), 890-901 (2018-02-01)
Crossbred beef bulls (n = 180) were blocked by initial BW (337 ± 10.9 kg; six blocks) and assigned randomly to one of three treatments on day 0: 1) INJ; received 1 mL (100 mg Zn) of a Zn solution
Michal Beker et al.
Frontiers in microbiology, 9, 1329-1329 (2018-07-13)
Strains of the Pasteurellaceae bacteria Pasteurella multocida and Mannheimia haemolytica are major etiological agents of bovine respiratory disease (BRD). Treatment of BRD with antimicrobials is becoming more challenging due to the increasing occurrence of resistance in infecting strains. In Pasteurellaceae
Saunders Handbook of Veterinary Drugs: Small and Large Animal (2015)
Yu-Feng Zhou et al.
BMC veterinary research, 16(1), 81-81 (2020-03-07)
Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. Our study aims to establish the clinical breakpoint and optimum dose regimen for gamithromycin against Haemophilus parasuis in piglets. Gamithromycin was well absorbed and fully bioavailable
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