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32002

Sigma-Aldrich

Sodium 5,5-diethylbarbiturate

purum, ≥99.0% (NT)

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Synonym(s):
5,5-Diethylbarbituric acid sodium salt, Barbitone, Sodium barbital, Veronal sodium salt
Empirical Formula (Hill Notation):
C8H11N2NaO3
CAS Number:
144-02-5
Molecular Weight:
206.17
Beilstein:
3921202
EC Number:
205-613-9
MDL number:
MFCD00036203
UNSPSC Code:
12161703
PubChem Substance ID:
329753946
NACRES:
NA.77

grade

purum

Quality Level

200

Assay

≥99.0% (NT)

form

powder or crystals

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

storage condition

(Tightly closed. Dry.)

technique(s)

GC/MS: suitable
HPLC: suitable
activity assay: suitable

color

colorless

pH

9.0-10.5

mp

>287.1 °C (> 548.8 °F)

solubility

water: soluble 103.1 g/L at 20 °C (68 °F)

density

1.418 g/cm3 at 20 °C ( 68 °F)

suitability

suitable for microbiology
suitable for molecular biology

application(s)

cell analysis

SMILES string

[Na+].CCC1(CC)C(=O)NC([O-])=NC1=O

InChI

1S/C8H12N2O3.Na/c1-3-8(4-2)5(11)9-7(13)10-6(8)12;/h3-4H2,1-2H3,(H2,9,10,11,12,13);/q;+1/p-1

InChI key

RGHFKWPGWBFQLN-UHFFFAOYSA-M

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General description

Sodium 5,5-diethyl barbiturate, also known as Barbital sodium, is a long-acting barbiturate that can significantly depress various metabolic processes at high doses. This weak acid has widespread applications in scientific fields, particularly as a buffering solution in biochemical and biological experiments due to its buffering capabilities. It is particularly well-suited for scenarios requiring lower buffer capacity without compromising pH stability. This buffering effect is achieved through the equilibrium between the acid and its corresponding anion, effectively stabilizing the pH within the desired range. Additionally, Sodium 5,5-diethyl barbiturate has potential applications in histology, and biochemical research, including uses in enzyme assays, cell structure staining, and electrophoresis.

Application

Sodium 5,5-diethyl barbiturate has been used as a component of Michaeli′s buffer, a commonly used buffer solution that helps maintain ideal conditions for histological and histopathological analyses. It is also utilized as a biological buffer in immunoelectrophoresis, hemolytic assays and fixative solutions.

Biochem/physiol Actions

Sedative/hypnotic

Features and Benefits

  • Suitable for electrophoresis and enzymatic assays
  • High purity product for research applications
  • Component of Michaeli′s buffer

Warning

Substance of abuse. Regulatory approval may be required for purchase. Comply with applicable laws. Exercise responsible use.

Other Notes

For additional information on our range of Biochemicals, please complete this form.
This product is intended for research purposes only, and it is not meant for human consumption.
Sales restrictions may apply

comparable product

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Description
Pricing

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 2 - STOT SE 3

Target Organs

Nervous system, Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C S Rinder et al.
The Journal of clinical investigation, 96(3), 1564-1572 (1995-09-01)
Complement activation contributes to the systemic inflammatory response induced by cardiopulmonary bypass. At the cellular level, cardiopulmonary bypass activates leukocytes and platelets; however the contribution of early (3a) versus late (C5a, soluble C5b-9) complement components to this activation is unclear.
Y Hiasa et al.
Carcinogenesis, 3(10), 1187-1190 (1982-01-01)
Phenobarbital (PB) and barbital (BB) promoted the development of thyroid tumors in rats treated with a sub-effective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN) for thyroid tumorigenesis. Rats were given s.c. injections of 70 mg DHPN/100 g body weight once a week for

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