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Sulfadoxin

VETRANAL®, analytical standard

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Synonym(s):
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide, Sulfadoxine
Empirical Formula (Hill Notation):
C12H14N4O4S
CAS Number:
2447-57-6
Molecular Weight:
310.33
Beilstein:
625453
EC Number:
219-504-9
MDL number:
MFCD00792890
UNSPSC Code:
41116107
PubChem Substance ID:
329753909
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC

InChI

1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI key

PJSFRIWCGOHTNF-UHFFFAOYSA-N

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General description

Chemical structure: sulfonamide
Sulfadoxin belongs to the long acting group of sulfonamides, which acts by inhibiting dihydropteroate synthase in intracellular sporozoa such as Eimeria and Toxoplasma and Plasmodium.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Sulfadoxin may be used as a reference standard for the determination of the analyte in plasma samples using packed-column supercritical fluid chromatography (SFC).

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Encyclopedic Reference of Parasitology, 2(2) (2001)
Determination of sulfadoxine in human blood plasma using packed-column supercritical fluid chromatography.
Bhoir IS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 757(1) (2001)
Alexia Daoust et al.
NeuroImage, 96, 133-142 (2014-04-08)
The MAP6 (microtubule-associated protein 6) KO mouse is a microtubule-deficient model of schizophrenia that exhibits severe behavioral disorders that are associated with synaptic plasticity anomalies. These defects are alleviated not only by neuroleptics, which are the gold standard molecules for
Shane A Pawluk et al.
Clinical pharmacokinetics, 52(3), 153-167 (2013-01-05)
Malaria is one of the most common parasitic infections worldwide. Plasmodium falciparum is the most prevalent strain in Africa and also the most fatal. The disease especially affects children, with those under age 5 years accounting for approximately 86 %
John J Aponte et al.
Lancet (London, England), 374(9700), 1533-1542 (2009-09-22)
Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa. We pooled data from six double-blind, randomised, placebo-controlled
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