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Supelco

Amprolium hydrochloride

VETRANAL®, analytical standard

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Synonym(s):
1-([4-Amino-2-propyl-5-pyrimidinyl]methyl)-2-methylpyridinium chloride
Linear Formula:
C14H19N4Cl · HCl
CAS Number:
137-88-2
Molecular Weight:
315.24
Beilstein:
4118699
EC Number:
205-307-5
MDL number:
MFCD00078831
UNSPSC Code:
41116107
PubChem Substance ID:
329753837
NACRES:
NA.24

grade

analytical standard

Quality Level

100

description

cationic

product line

VETRANAL®

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

mol wt

315.24 g/mol

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

SMILES string

[Cl-].Cl[H].CCCc1ncc(C[n+]2ccccc2C)c(N)n1

InChI

1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1

InChI key

PJBQYZZKGNOKNJ-UHFFFAOYSA-M

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Application

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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X Wang et al.
Neuroscience, 144(3), 1045-1056 (2006-12-02)
Thiamine (vitamin B1) deficiency (TD) causes region selective neuronal loss in the brain; it has been used to model neurodegeneration that accompanies mild impairment of oxidative metabolism. The mechanisms for TD-induced neurodegeneration remain incompletely elucidated. Inhibition of protein glycosylation, perturbation
Zun-Ji Ke et al.
Alcoholism, clinical and experimental research, 33(6), 1097-1103 (2009-04-23)
Heavy alcohol consumption causes cerebellar degeneration, and the underlying mechanism is unclear. Chronic alcoholism is usually associated with thiamine deficiency (TD) which is known to induce selective neurodegeneration in the brain. However, the role of TD in alcohol-induced cerebellar degeneration
D Bizon-Zygmańska et al.
Neurochemistry international, 59(2), 208-216 (2011-06-16)
Inhibition of pyruvate (PDHC) and ketoglutarate (KDHC) dehydrogenase complexes induced by thiamine pyrophosphate deficits is known cause of disturbances of cholinergic transmission in the brain, yielding clinical symptoms of cognitive, vegetative and motor deficits. However, particular alterations in distribution of
N E Nweze et al.
Journal of ethnopharmacology, 122(1), 6-9 (2008-12-17)
Ageratum conyzoides (Asteraceae) is folklorically used to treat diseases associated with bleeding. A study was conducted to determine the efficacy of Ageratum conyzoides in treating caecal coccidiosis of broilers. Acute toxicity test was done using thirty 28 days old broiler
Mohamed M Ghanem et al.
Preventive veterinary medicine, 84(1-2), 161-170 (2008-02-12)
We compared the therapeutic effect of three anticoccidial drugs (toltrazuril, sulphadimidine and amprolium) in buffalo (Bubalus bubalis) calves experimentally infected with Eimeria bovis (E. bovis) and E. zuernii oocysts (3 x 104oocyst/calf). Buffalo calves (1.5-4 month old, 70-kg body weight)
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