25745
Chloroquine diphosphate salt
≥96.0% (TLC)
Synonym(s):
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
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About This Item
Empirical Formula (Hill Notation):
C18H26ClN3 · 2H3PO4
CAS Number:
Molecular Weight:
515.86
EC Number:
200-055-2
UNSPSC Code:
12161501
MDL number:
Beilstein/REAXYS Number:
4223142
InChI
1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
InChI key
QKICWELGRMTQCR-UHFFFAOYSA-N
SMILES string
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
assay
≥96.0% (TLC)
impurities
≤3% water
solubility
H2O: 50 mg/mL, clear
mode of action
enzyme | inhibits
Other Notes
Lysosomotropic drug
This product has been replaced by C6628-SIGMA | Chloroquine diphosphate salt solid, ≥98%
Regulatory Information
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D.D. Hong
Anal. Profiles Drug Subst., 5, 61-61 (1976)
[A case of imported vivax malaria in Tomsk].
N P Chernyshova et al.
Meditsinskaia parazitologiia i parazitarnye bolezni, (4)(4), 49-50 (2013-02-27)
Claudia G C Cisneros et al.
Acta dermato-venereologica, 90(2), 175-178 (2010-02-20)
Toxic epidermal necrolysis-like lesions have been described in the setting of lupus erythematosus, and have been considered as a specific hyperacute variant of cutaneous lupus erythematosus, with features different from classical drug-related toxic epidermal necrolysis. We report here a series
Pei-Du Jiang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 64(9), 609-614 (2010-10-05)
Metastatic breast cancers are hard to treat and almost always fatal. Chloroquine diphosphate, a derivative of quinine, has long been used as a potent and commonly used medicine against different human diseases. We therefore investigated the effects of chloroquine diphosphate
Ketaki R Desai et al.
Drug and chemical toxicology, 35(2), 184-191 (2011-07-22)
The present study was conducted to screen the efficacy of curcumin against chloroquine phosphate (CQ)-induced reproductive toxicity in adult male Swiss albino mice. Animals were given oral doses of 100, 200, 300 mg/kg body weight (b.w.), and high dose of CQ
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