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Calcium ionophore II

Selectophore™, function tested

Synonym(s):

N,N,N′,N′-Tetra[cyclohexyl]diglycolic acid diamide, N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide, ETH 129

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About This Item

Empirical Formula (Hill Notation):
C28H48N2O3
CAS Number:
74267-27-9
Molecular Weight:
460.69
Beilstein:
6491651
MDL number:
MFCD00043337
UNSPSC Code:
26111700
PubChem Substance ID:
329752116
NACRES:
NB.61

grade

for ion-selective electrodes

Quality Level

200

product line

Selectophore™

form

solid

quality

function tested

SMILES string

O=C(COCC(=O)N(C1CCCCC1)C2CCCCC2)N(C3CCCCC3)C4CCCCC4

InChI

1S/C28H48N2O3/c31-27(29(23-13-5-1-6-14-23)24-15-7-2-8-16-24)21-33-22-28(32)30(25-17-9-3-10-18-25)26-19-11-4-12-20-26/h23-26H,1-22H2

InChI key

URAUKAJXWWFQSU-UHFFFAOYSA-N

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General description

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Application

Selected application examples
Calcium ionophore II (ETH 129) was used in preparing calcium selective minielectrodes which are used in determination of dissociation constant (Kd).
Suitable for intracellular calcium measurements.
Lipophilic ionophore for Ca2+-selective electrodes with detection limit in the sub-nanomolar range. Extremely efficient carrier of Ca2+-ions; induces a selectivity in membranes for Ca2+ over Mg2+ by a factor of about 104.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
60824/2
AR060824/2
AR60824/2
060824/2V
060824/2

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Mariya V Kovaleva et al.
Journal of bioenergetics and biomembranes, 41(3), 239-249 (2009-07-18)
In this study we used tightly-coupled mitochondria from Yarrowia lipolytica and Dipodascus (Endomyces) magnusii yeasts, possessing a respiratory chain with the usual three points of energy conservation. High-amplitude swelling and collapse of the membrane potential were used as parameters for
Y L Ma et al.
Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 12(2), 98-102 (1992-01-01)
A calcium ion-selective PVC membrane electrode based on neutral carrier n,n,n',n'-tetracyclohexyl-3-oxapetanediamide, using di-(2-ethylhexyl)phthalate as the plasticizer and potassium tetrakis (4-chlorophenyl) borate as the additive is reported in this paper. The ion selective membrane consists of 1 wt% of the Ca2+
Iwona Bedlechowicz-Sliwakowska et al.
Analytical and bioanalytical chemistry, 385(8), 1477-1482 (2006-07-19)
In this work, ion-selective electrodes for calcium ion were investigated. Two ionophores were used in the membranes: ETH 1001 and ETH 129. An internal filling solution buffered for primary ion was used that allowed the lower detection limit to be
G Prestipino et al.
Analytical biochemistry, 210(1), 119-122 (1993-04-01)
We have investigated the ability of the neutral ionophore ETH 129 to translocate Ca2+ across artificial and biological membranes. ETH 129 induces Ca2+ transport across planar lipid bilayer. The zero-current membrane potential in a gradient of Ca2+ concentration exhibits Nernst
Patrick C Bradshaw et al.
BMC biochemistry, 7, 4-4 (2006-02-08)
Divalent cations are required for many essential functions of mitochondrial metabolism. Yet the transporters that mediate the flux of these molecules into and out of the mitochondrion remain largely unknown. Previous studies in yeast have led to the molecular identification
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