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198218

Sigma-Aldrich

Patent Blue VF

Dye content 50 %

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Synonym(s):
Acid Blue 1, Sulfan Blue
Empirical Formula (Hill Notation):
C27H31N2NaO6S2
CAS Number:
129-17-9
Molecular Weight:
566.66
Colour Index Number:
42045
EC Number:
204-934-1
MDL number:
MFCD00012119
UNSPSC Code:
12171500
PubChem Substance ID:
24851867
NACRES:
NA.47

form

powder

Quality Level

200

composition

Dye content, 50%

solubility

H2O: 1 mg/mL

λmax

635 nm (2nd)
-410 nm

ε (extinction coefficient)

≥50000 at 635-641 nm in H2O
≥5300 at 408-414 nm in H2O
≥7500 at 308-314 nm in H2O

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CCN(CC)c1ccc(cc1)\C(=C2/C=CC(\C=C2)=[N+](\CC)CC)c3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-18-17-24(36(30,31)32)19-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1

InChI key

SJEYSFABYSGQBG-UHFFFAOYSA-M

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Application

Patent Blue VF has been used:
  • in combination with 99mTc phytate to detect sentinel lymph node (SLN) in early stage cervical cancer patients.
  • to detect heat shock protein (HSP) gp96 induced draining lymph nodes (LNs) in mice.
  • to detect the effect of Asn-Gly-Arg (NGR)-tumor necrosis factor (TNF) on tumor perfusion in murine model.

Biochem/physiol Actions

Patent Blue VF dye is a violet colored powder. It has been used in cosmetic coloring.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Blue dyes in medicine--a confusing terminology.
Kathrin Scherer et al.
Contact dermatitis, 54(4), 231-232 (2006-05-03)
Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue.
Niikura H
Gynecologic Oncology, 94(2), 528-532 (2004)
Synergistic antitumor activity of cisplatin, paclitaxel, and gemcitabine with tumor vasculature-targeted tumor necrosis factor-alpha.
Sacchi A
Clinical Cancer Research, 12(1), 175-182 (2006)
Effect of Patent Blue V(®) dye on sample interference indices on the Abbott Architect.
Malcolm P McTaggart et al.
Annals of clinical biochemistry, 49(Pt 5), 510-511 (2012-08-24)
David Pavlista et al.
Annals of surgical oncology, 19(11), 3410-3415 (2012-04-25)
This anatomic study details the lymphatic drainage of the upper extremity (UE) and breast, as well as its course in the axilla and its relation to axillary reverse mapping. Two aspects important for breast cancer surgery were followed: connection between
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