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Merck
CN

18224

Fraxetin

analytical standard

Synonym(s):

7,8-Dihydroxy-6-methoxycoumarin, Fraxetin

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About This Item

Empirical Formula (Hill Notation):
C10H8O5
CAS Number:
574-84-5
Molecular Weight:
208.17
NACRES:
NA.24
PubChem Substance ID:
329751653
UNSPSC Code:
85151701
EC Number:
209-376-2
MDL number:
MFCD00006873

Key Documents

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InChI key

HAVWRBANWNTOJX-UHFFFAOYSA-N

InChI

1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3

SMILES string

COc1cc2C=CC(=O)Oc2c(O)c1O

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤2.5% water (calc. from elemental analysis)

mp

230-231 °C (lit.)

application(s)

food and beverages

format

neat

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF4595
BCCF1050
BCCF0511
BCCB6821
BCBX5336

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Miguel Nemesio-Gorriz et al.
Journal of experimental botany, 71(19), 6074-6083 (2020-07-01)
Ash dieback, a forest epidemic caused by the invasive fungus Hymenoscyphus fraxineus, threatens ash trees throughout Europe. Within Fraxinus excelsior populations, a small proportion of genotypes show a low susceptibility to the pathogen. We compared the metabolomes from a cohort
Jisoo Song et al.
Pharmaceutics, 13(1) (2021-01-23)
Fraxetin is a coumarin scaffold compound extracted from Fraxinus rhynchophylla. It has antioxidant, anti-inflammatory, hepatoprotective, and antifibrotic effects. Furthermore, fraxetin has anticancer effects in breast and lung cancer. We aimed to evaluate whether fraxetin has anticancer activity in hepatocellular carcinoma
Christopher J Harbort et al.
Cell host & microbe, 28(6), 825-837 (2020-10-08)
Plants benefit from associations with a diverse community of root-colonizing microbes. Deciphering the mechanisms underpinning these beneficial services are of interest for improving plant productivity. We report a plant-beneficial interaction between Arabidopsis thaliana and the root microbiota under iron deprivation

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