16499
Ipriflavone
analytical standard
Synonym(s):
7-Isopropoxy-3-phenyl-4H-1-benzopyran-4-one, Ipriflavone
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About This Item
Empirical Formula (Hill Notation):
C18H16O3
CAS Number:
Molecular Weight:
280.32
UNSPSC Code:
85151701
PubChem Substance ID:
MDL number:
InChI
1S/C18H16O3/c1-12(2)21-14-8-9-15-17(10-14)20-11-16(18(15)19)13-6-4-3-5-7-13/h3-12H,1-2H3
SMILES string
CC(C)Oc1ccc2c(OC=C(C2=O)c3ccccc3)c1
InChI key
SFBODOKJTYAUCM-UHFFFAOYSA-N
grade
analytical standard
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
116-120 °C (lit.)
format
neat
Quality Level
General description
Ipriflavone, a flavonoid derivative of the natural isoflavone compound, plays a role in the mitochondrial phosphorylation and exhibits growth-promoting activity.
Application
Ipriflavone can be used as an analytical standard for the determination of the analyte in human and animal biological samples by liquid chromatography (LC) based methods.
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Simultaneous determination of ipriflavone and its main metabolites M1 and M5 in human plasma by liquid chromatography with tandem mass spectrometry
Ji HY, et al.
Analytical Letters, 38(1), 99-110 (2005)
Determination of ipriflavone and its synthetic impurities by high-performance liquid chromatography using diode-array detection
Sustacha K, et al.
Journal of Chromatography A, 719(1), 245-250 (1996)
Disposition of ipriflavone (TC-80) in rats and dogs.
Yoshida K, et al.
Radioisotopes, 34(11), 618-623 (1985)
Hye J Chung et al.
The Journal of pharmacy and pharmacology, 58(4), 449-457 (2006-04-07)
In order to find out what types of the hepatic microsomal cytochrome P450 (CYP) isozymes are involved in the metabolism of ipriflavone, ipriflavone at a dose of 20 mg kg(-1) (or 15 mg kg(-1)) was infused in male Sprague-Dawley rats.
H J Chung et al.
Research in veterinary science, 85(1), 149-155 (2007-10-09)
It has been reported that ipriflavone was primarily metabolized via hepatic microsomal cytochrome P450 (CYP) 1A1/2 and 2C11 in rats, and the expression of hepatic CYP1A2 and 2C11 was not changed in rats with water deprivation for 72h compared to
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