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Supelco

2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate

pharmaceutical impurity standard

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Synonym(s):
Aciclovir Related Compound A (USP), Aciclovir impurity A (PhEur)
Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
Molecular Weight:
267.24
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

grade

analytical standard

Assay

≥90.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤10.0% HPLC impurities
≤5% related solvents
≤5% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CC(=O)OCCOCn1cnc2C(=O)NC(N)=Nc12

InChI

1S/C10H13N5O4/c1-6(16)19-3-2-18-5-15-4-12-7-8(15)13-10(11)14-9(7)17/h4H,2-3,5H2,1H3,(H3,11,13,14,17)

InChI key

DMHAXLGAKQREIL-UHFFFAOYSA-N

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General description

2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate (impurity A) is the acetate form of acyclovir. It can be path indicative in the synthesis of acyclovir.
2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]ethyl acetate (impurity A) is the acetate form of acyclovir. It can be path indicative in the synthesis of acyclovir.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Muta. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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A L Huidobro et al.
Journal of pharmaceutical and biomedical analysis, 37(4), 687-694 (2005-03-31)
Acyclovir, guanine, and impurity A have been baseline separated with isocratic conditions at pH=3.0 and run time under 15 min by employing a SB-CN column from Agilent (150 mm x 4.6mm and 3.5 microm). Moreover, when run time was increased

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