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Merck
CN

15716

Boron trifluoride-methanol solution

~10% (~1.3 M), derivatization grade (GC derivatization), LiChropur™

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About This Item

Linear Formula:
BF3 · MeOH
CAS Number:
373-57-9
Molecular Weight:
99.85
UNSPSC Code:
12352104
NACRES:
NA.05
PubChem Substance ID:
329750982
EC Number:
206-766-4
Beilstein/REAXYS Number:
3611499
MDL number:
MFCD00071635

Key Documents

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Product Name

Boron trifluoride-methanol solution, ~10% (~1.3 M), derivatization grade (GC derivatization), LiChropur™

InChI key

JBXYCUKPDAAYAS-UHFFFAOYSA-N

InChI

1S/CH4O.BF3/c1-2;2-1(3)4/h2H,1H3;

SMILES string

CO.FB(F)F

grade

derivatization grade (GC derivatization)

Quality Level

100

product line

LiChropur™

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Esterifications

concentration

~10% (~1.3 M)

technique(s)

gas chromatography (GC): suitable

density

0.86 g/mL at 20 °C

storage temp.

2-8°C

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Application

Learn more in the Product Information
Boron trifluoride-methanol solution may be used for catalysing a method, used for the synthesis of bishydroperoxides and their derivatives, based on a reaction of ketals with a solution of hydrogen peroxide in anhydrous ether. It may also be used for the rapid preparation of fatty acid esters for gas chromatographic analysis, as it converts fatty acids to their respective methyl esters in about 2 minutes.
Suitable for derivatization of hydroxy fatty acids.

General description

Boron trifluoride (BF3) is a Lewis acid; it is a very useful reagent for forming esters from acids. Boron trifluoride is commercially available as a 14% solution in methanol for forming esters derivatives. It catalysed reactions carried out in a water bath are very rapid and can be completed in a few minutes. Boron-trifluoride-catalysed transesterification of vegetable oils is one of the most popular methods. For transesterification of vegetable oils, BF3 is used in methanol (15 to 20% w/v).

Other Notes

Reagent for esterifying fatty acid for gas chromatographic analysis.
Reagent for methyl ester, O-acetyl.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT RE 2 Inhalation - STOT SE 1

target_organs

Eyes,Central nervous system, Kidney

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

49.5 °F

flash_point_c

9.7 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN8136
BCCN4012
BCCN2248
BCCM9300
BCCM6468

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Introduction to Analytical Gas Chromatography, 219-219 (1997)
H. Rotzsche
Journal of Chromatography A, 552, 281-281 (1991)
The rapid preparation of fatty acid esters for gas chromatographic analysis.
Metcalfe LD and Schmitz AA.
Analytical Chemistry, 33 (3), 363-364 (1961)
Christian F Ruiz et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10574-10589 (2020-06-23)
Cancer cells require extensive metabolic reprograming in order to provide the bioenergetics and macromolecular precursors needed to sustain a malignant phenotype. Mutant KRAS is a driver oncogene that is well-known for its ability to regulate the ERK and PI3K signaling
A new method for the synthesis of bishydroperoxides based on a reaction of ketals with hydrogen peroxide catalyzed by boron trifluoride complexes.
Alexander TO
Tetrahedron Letters, 44 (39), 7359-7363 (2003)
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