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14872

Sigma-Aldrich

BICINE

≥99.0% (T)

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Synonym(s):
N,N-Bis(2-hydroxyethyl)glycine
Empirical Formula (Hill Notation):
C6H13NO4
CAS Number:
150-25-4
Molecular Weight:
163.17
Beilstein:
1769362
EC Number:
205-755-1
MDL number:
MFCD00004295
UNSPSC Code:
12161700

Assay

≥99.0% (T)

ign. residue

≤0.5%

loss

≤0.5% loss on drying, 20 °C (HV)

useful pH range

7.6-9.0

pKa (20 °C)

8.3

pKa (25 °C)

8.3

solubility

H2O: 0.1 g/mL at 20 °C, clear

anion traces

chloride (Cl-): ≤500 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

OCCN(CCO)CC(O)=O

InChI

1S/C6H13NO4/c8-3-1-7(2-4-9)5-6(10)11/h8-9H,1-5H2,(H,10,11)

InChI key

FSVCELGFZIQNCK-UHFFFAOYSA-N

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Application

Recommended buffer for low temperature biochemical work. Used in the preparation of stable substrate solution for serum guanase determination. Spacer in plasma protein fractionation with Sephadex® by isotachophoresis.

Legal Information

Sephadex is a registered trademark of Cytiva

replaced by

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R N Roy et al.
Cryobiology, 21(6), 672-681 (1984-12-01)
The establishment of the pH (designated pH*) of a standard buffer solution suitable as a pH reference in 30, 40, and 50 mass% dimethyl sulfoxide (DMSO)/H2O mixtures at temperatures in the range -20 to 0 degrees C is reported. The
Yoshiteru Seo et al.
Magnetic resonance in medicine, 65(4), 1005-1012 (2011-03-18)
The toxicity of free Mn(2+) is a bottleneck for the in vivo application of manganese ion enhanced MRI. To reduce free Mn(2+) concentration ([Mn(2+) ]), a low affinity chelate reagent: N,N-bis(2-hydroxyethyl)glycine (bicine) was used. Considering the conditional association constant of
E Gopinath et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(9), 3041-3044 (1989-05-01)
The nature and rate of reduction of Hg2+ to Hg0 by 1,5-dihydro-3,(3-sulfopropyl)lumiflavin (FIH2) in buffered aqueous solutions (pH 4.7) is dependent on the ligation of Hg2+. In the presence of N,N-bis(2-hydroxyethyl)glycine or when ligated to ethylenediaminetetraacetic acid, the reduction is
S Ito et al.
The Histochemical journal, 16(5), 489-499 (1984-05-01)
Histochemical studies of human guanase (guanine deaminase) have seldom been undertaken, in part because of technical difficulties which result in heavy background staining. In this report, we describe a modified procedure in which the methodological inadequacies have been overcome. The
The myosin dimer: an intermediate in the self-assembly of the thick filament of vertebrate skeletal muscle.
J S Davis et al.
FEBS letters, 140(2), 293-297 (1982-04-19)
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