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131105

Sigma-Aldrich

3,6-Diaminoacridine hydrochloride

Dye content 95 %

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Synonym(s):
Proflavine hydrochloride, Proflavine monohydrochloride
Empirical Formula (Hill Notation):
C13H11N3 · HCl
CAS Number:
952-23-8
Molecular Weight:
245.71
EC Number:
213-459-9
MDL number:
MFCD00066867
UNSPSC Code:
12171500
PubChem Substance ID:
24847995
NACRES:
NA.47

Assay

94.0% (HPLC)

form

powder

composition

Dye content, 95%

mp

270 °C (dec.) (lit.)

solubility

H2O: 1 mg/mL, clear

λmax

456 nm

ε (extinction coefficient)

50000 at 260 nm in methanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Cl[H].Nc1ccc2cc3ccc(N)cc3nc2c1

InChI

1S/C13H11N3.ClH/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;/h1-7H,14-15H2;1H

InChI key

PBBGTVBGXBUVLT-UHFFFAOYSA-N

Related Categories

Application

3, 6-Diaminoacridine hydrochloride has been used for studying cation transfer at the liquid–liquid interface.
An intercalating dye.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Miklós Nagy et al.
Scientific reports, 9(1), 8250-8250 (2019-06-05)
Amino-isocyanoacridines (ICAAcs), as first members of their class, turned out to be a novel, multifunctional acridine orange (AO) type dye family with a number of additional favorable properties. They have enhanced solvatochromic emission range, low quantum yields (ΦF = 2.9-0.4%) in water
Anna Porfireva et al.
Nanomaterials (Basel, Switzerland), 10(5) (2020-05-14)
A DNA sensor has been developed for the determination of doxorubicin by consecutive electropolymerization of an equimolar mixture of Azure B and proflavine and adsorption of native DNA from salmon sperm on a polymer film. Electrochemical investigation showed a difference
Anirban Basu et al.
Journal of biomolecular structure & dynamics, 38(6), 1590-1597 (2019-05-07)
The binding of proflavine, an acriflavine derivative, with the RNA polynucletodide polyadenylic acid-polyuridylic acid is investigated here to understand the structural and thermodynamic basis of the binding process. Such binding data are crucial for designing viable theraperutic agents. Spectroscopic studies
Anirban Basu et al.
Journal of photochemistry and photobiology. B, Biology, 165, 42-50 (2016-10-22)
Interaction of proflavine with hemoglobin (Hgb) was studied employing spectroscopy, calorimetry, and atomic force microscopy. The equilibrium constant was found to be of the order 10
Membrane activity of ionisable drugs ? a task for liquid?liquid electrochemistry?
Malkia A
Electrochemical Communications, 5:6, 473-479 (2003)
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