09658
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate
≥98.0% (T)
Synonym(s):
TCFH
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About This Item
Empirical Formula (Hill Notation):
C5H12ClF6N2P
CAS Number:
Molecular Weight:
280.58
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7896715
Product Name
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate, ≥98.0% (T)
InChI
1S/C5H12ClN2.F6P/c1-7(2)5(6)8(3)4;1-7(2,3,4,5)6/h1-4H3;/q+1;-1
SMILES string
F[P-](F)(F)(F)(F)F.CN(C)\C(Cl)=[N+](\C)C
InChI key
CUKNPSDEURGZCO-UHFFFAOYSA-N
assay
≥98.0% (T)
reaction suitability
reaction type: Coupling Reactions
mp
99-112 °C
application(s)
peptide synthesis
storage temp.
2-8°C
Quality Level
Application
Chloro-N,N,N′,N′-tetramethylformamidinium hexafluorophosphate can be used as a reactant for the synthesis of:
It can also be used as a reagent for the synthesis of:
- Onium salts for use in peptide coupling.
- Benzotriazole based uranium reagent, a safer replacement for coupling reagents.
It can also be used as a reagent for the synthesis of:
- Cancer cell cytotoxins.
- Bioconjugation reagents.
Other Notes
Coupling reagent for peptide synthesis and starting material for preparing other coupling reagents
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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A novel family of onium salts based upon isonitroso meldrum's acid proves useful as peptide coupling reagents
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COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents
El-Faham A, et al.
Chemistry?A European Journal , 15(37), 9404-9416 (2009)
An Evaluation of the Occupational Health Hazards of Peptide Couplers
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Chemical Research in Toxicology, 35(6), 1011?1022-1011?1022 (2022)
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