07635
Puromycin aminonucleoside
≥99.0% (HPLC)
Synonym(s):
3′-Amino-3′-deoxy-N6,N6-dimethyladenosine
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About This Item
Empirical Formula (Hill Notation):
C12H18N6O3
CAS Number:
Molecular Weight:
294.31
EC Number:
200-388-3
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
93902
InChI
1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1
InChI key
RYSMHWILUNYBFW-VENHTOENSA-N
SMILES string
CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O
assay
≥99.0% (HPLC)
solubility
H2O: 50 mg/mL, clear, slightly yellow
mode of action
protein synthesis | interferes
storage temp.
2-8°C
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Leyi Gu et al.
Kidney international, 81(5), 458-468 (2011-12-15)
In non-neuronal cells, glutamate is an extracellular signaling mediator. Since podocytes have glutamate-containing vesicles, we sought to determine glutamate receptor presence and action in glomerular cells. The metabotropic glutamate receptors (mGluR) 1, 5, 6, and 8 were found to be
Xuan Bu et al.
American journal of physiology. Renal physiology, 301(4), F784-F792 (2011-07-22)
Podocyte injury is considered to play important roles in the pathogenesis of human glomerular disease. There is accumulating evidence suggesting that hepatocyte growth factor (HGF) elicits preventive activity for glomerular cells in animal models of chronic renal diseases. In this
G N Marinides et al.
Kidney international, 37(2), 749-757 (1990-02-01)
The effects of dietary protein and converting enzyme inhibition (CEI) on chronic puromycin aminonucleoside nephropathy (PAN) were studied. PAN was induced with seven SQ injections of puromycin aminonucleoside 20 mg/kg over 10 weeks in male Sprague-Dawley rats. The rats were
Donghai Wen et al.
American journal of nephrology, 34(5), 423-434 (2011-09-29)
Nestin is an intermediate filament protein widely used as a marker of stem cells or progenitor cells. Nestin is also highly expressed in the glomerular podocyte, a type of terminally differentiated epithelial cell. Little is known about the significance of
Satoshi Kinugasa et al.
Medical molecular morphology, 43(4), 218-225 (2011-01-27)
To show the three-dimensional distribution of proteins in renal cells, we applied the immunogold scanning electron microscopy method using vibratome slices. Kidney specimens from puromycin aminonucleoside (PAN) nephrotic rats and controls were obtained after intravenous infusion of human serum albumin
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