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Safety Information

07635

Sigma-Aldrich

Puromycin aminonucleoside

≥99.0% (HPLC)

Synonym(s):

3′-Amino-3′-deoxy-N6,N6-dimethyladenosine

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About This Item

Empirical Formula (Hill Notation):
C12H18N6O3
CAS Number:
58-60-6
Molecular Weight:
294.31
Beilstein:
93902
EC Number:
200-388-3
MDL number:
MFCD00063462
UNSPSC Code:
12352200

Assay

≥99.0% (HPLC)

solubility

H2O: 50 mg/mL, clear, slightly yellow

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

CN(C)c1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](N)[C@@H]3O

InChI

1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3/t6-,7+,9+,12-/m1/s1

InChI key

RYSMHWILUNYBFW-VENHTOENSA-N

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Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H373

Hazard Classifications

STOT RE 2

Target Organs

Kidney

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Yiqin Zuo et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 27(1), 174-181 (2011-05-14)
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have beneficial effects on renal structure and function in models of diabetes and chronic kidney diseases. However, the increased incidence of weight gain and edema potentially limits their usefulness. We studied an acute minimal-change
Satoshi Kinugasa et al.
Medical molecular morphology, 43(4), 218-225 (2011-01-27)
To show the three-dimensional distribution of proteins in renal cells, we applied the immunogold scanning electron microscopy method using vibratome slices. Kidney specimens from puromycin aminonucleoside (PAN) nephrotic rats and controls were obtained after intravenous infusion of human serum albumin
Donghai Wen et al.
American journal of nephrology, 34(5), 423-434 (2011-09-29)
Nestin is an intermediate filament protein widely used as a marker of stem cells or progenitor cells. Nestin is also highly expressed in the glomerular podocyte, a type of terminally differentiated epithelial cell. Little is known about the significance of
Xuan Bu et al.
American journal of physiology. Renal physiology, 301(4), F784-F792 (2011-07-22)
Podocyte injury is considered to play important roles in the pathogenesis of human glomerular disease. There is accumulating evidence suggesting that hepatocyte growth factor (HGF) elicits preventive activity for glomerular cells in animal models of chronic renal diseases. In this
G N Marinides et al.
Kidney international, 37(2), 749-757 (1990-02-01)
The effects of dietary protein and converting enzyme inhibition (CEI) on chronic puromycin aminonucleoside nephropathy (PAN) were studied. PAN was induced with seven SQ injections of puromycin aminonucleoside 20 mg/kg over 10 weeks in male Sprague-Dawley rats. The rats were
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