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07386

Supelco

Coenzyme Q10

analytical standard

Synonym(s):

Q-10, Ubiquinone 50, Ubiquinone-10

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About This Item

Empirical Formula (Hill Notation):
C59H90O4
CAS Number:
303-98-0
Molecular Weight:
863.34
Beilstein:
1900141
EC Number:
206-147-9
MDL number:
MFCD00042919
UNSPSC Code:
85151701
PubChem Substance ID:
329748422
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97.5% (HPLC)

form

powder

shelf life

limited shelf life, expiry date on the label

impurities

≤1.0% water

color

faint yellow to dark orange

mp

49 °C

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

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General description

Coenzyme Q10 is the central electron carrier in mitochondrial respiratory chain, originating from food intake as well as from endogenous synthesis. It commonly acts in its reduced form to prevent lipid peroxidation in biological membranes and in serum low-density lipoproteins (LDL). It also tends to protect the mitochondrial membrane proteins and DNA against oxidative damage along with lipid peroxidation.

Application


  • Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-kB/NLRP3 inflammasome axis and attenuating oxidative stress in mice: Research demonstrates Coenzyme Q10′s effectiveness in reducing cardiac damage through antioxidant mechanisms and inflammation modulation, offering insights for potential human therapeutic applications (Antar et al., 2024).

  • Adverse hematological profiles associated with chlorpromazine antipsychotic treatment in male rats: Preventive and reversal mechanisms of taurine and coenzyme-Q10: This study explores how Coenzyme Q10, along with taurine, can mitigate the negative hematological effects of chlorpromazine, suggesting its use in managing side effects in psychiatric treatments (Obukohwo et al., 2024).

  • Nutritional Strategies for Muscle Atrophy: Current Evidence and Underlying Mechanisms: Discusses the role of Coenzyme Q10 in muscle health, particularly in preventing atrophy through mitochondrial support and enhancing cellular energy metabolism, pertinent for sports medicine and aging (Shen et al., 2024).

  • Identification of a family of species-selective complex I inhibitors as potential anthelmintics: Although indirectly related, this study hints at the role of mitochondrial function, which could be linked to Coenzyme Q10′s effects in similar pathways, suggesting a novel application area in parasitology and infectious diseases (Davie et al., 2024).

Caution

light sensitive

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Simultaneous analysis of coenzyme Q10 in plasma, erythrocytes and platelets: comparison of the antioxidant level in blood cells and their environment in healthy children and after oral supplementation in adults
Niklowitz P, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 342(1-2), 219-226 (2004)
D Orsucci et al.
Current medicinal chemistry, 18(26), 4053-4064 (2011-08-10)
Coenzyme Q10 is a small electron carrier of the respiratory chain with antioxidant properties, widely used for the treatment of mitochondrial disorders. Mitochondrial diseases are neuromuscular disorders caused by impairment of the respiratory chain and increased generation of reactive oxygen
Shirin Kalyan et al.
The Journal of clinical endocrinology and metabolism, 99(4), 1307-1313 (2014-01-16)
Nitrogen-bisphosphonates (N-BPs) are the most widely used drugs for bone fragility disorders. Long-term or high-dose N-BP use is associated with unusual serious side effects such as osteonecrosis of the jaw, musculoskeletal pain, and atypical fractures of long bones. It has
Gerwyn Morris et al.
Molecular neurobiology, 48(3), 883-903 (2013-06-14)
Coenzyme Q10 (CoQ10) is an antioxidant, a membrane stabilizer, and a vital cofactor in the mitochondrial electron transport chain, enabling the generation of adenosine triphosphate. It additionally regulates gene expression and apoptosis; is an essential cofactor of uncoupling proteins; and
Adarsh Kumar et al.
Pharmacology & therapeutics, 124(3), 259-268 (2009-07-30)
Coenzyme Q10 (ubiquinone) is a mitochondrial coenzyme which is essential for the production of ATP. Being at the core of cellular energy processes it assumes importance in cells with high energy requirements like the cardiac cells which are extremely sensitive
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