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07270

Sigma-Aldrich

Methyl 6-aminohexanoate hydrochloride

≥99.0% (AT)

Synonym(s):

Methyl 6-aminocaproate hydrochloride

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About This Item

Linear Formula:
NH2(CH2)5COOCH3 · HCl
CAS Number:
1926-80-3
Molecular Weight:
181.66
Beilstein:
3687692
MDL number:
MFCD00035455
UNSPSC Code:
12352200
PubChem Substance ID:
329748390
NACRES:
NA.22

Quality Level

200

Assay

≥99.0% (AT)

form

powder or crystals

reaction suitability

reaction type: solution phase peptide synthesis

color

white

mp

117-124 °C

application(s)

peptide synthesis

SMILES string

Cl.COC(=O)CCCCCN

InChI

1S/C7H15NO2.ClH/c1-10-7(9)5-3-2-4-6-8;/h2-6,8H2,1H3;1H

InChI key

YSLDOTFAFZJPOC-UHFFFAOYSA-N

Related Categories

General description

Methyl 6-aminohexanoate hydrochloride also known as Methyl 6-aminocaproate hydrochloride, is commonly used in the solution-phase peptide synthesis.

Application

Methyl 6-aminohexanoate hydrochloride is used to synthesize papain-catalyzed peptides.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Herein, the biodegradable micelle-forming amphiphilic N-(2-hydroxypropyl) methacrylamide (HPMA)-based polymer conjugates with the anticancer drug doxorubicin (Dox) designed for enhanced tumor accumulation were investigated, and the influence of their stability in the bloodstream on biodistribution, namely, tumor uptake, and in vivo
Tomáš Etrych et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 58, 1-12 (2014-03-19)
In this study, we describe the synthesis, physico-chemical characterisation and results of the in vitro and in vivo evaluation of the biological behaviour of N-(2-hydroxypropyl)methacrylamide-based (HPMA) copolymer conjugates bearing doxorubicin (DOX) partly bound via a pH-sensitive hydrazone and partly via
Martin Studenovský et al.
Anticancer research, 35(2), 753-757 (2015-02-11)
In the present study, we describe the synthesis and physicochemical properties of a novel pH- and thermoresponsive micellar drug delivery system for an anticancer ellipticinium derivative based on the triblock copolymer poly(ethylene oxide)-block-[tert-butylacrylamide-co-6-(N-methacryloylamino)hexanoic acid hydrazide]-block-poly(ethylene oxide). The system was designed

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