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Sigma-Aldrich

Spermidine 0.1 M solution

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Synonym(s):
Spermidine solution, Additive Screening Solution 30/Kit-No 78374
CAS Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

Quality Level

density

1.00 g/mL at 20 °C

storage temp.

2-8°C

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Gene Information

mouse ... Odc1(18263)
rat ... Ppm1a(24666)

Biochem/physiol Actions

Spermidine is a naturally occurring polyamine. It is associated with various cellular functions. It is responsible for the condensation and aggregation of DNA in aqueous solution. Spermidine is known to extend lifespan via epigenetic modifications, induction of cell death and inhibition of necrosis.
Spermidine 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Induction of autophagy by spermidine promotes longevity.
Eisenberg T et al.
Nature Cell Biology, 11, 1305-1305 (2009)
53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) and National Meeting of Chemistry of Biological Systems ? Italian Chemical Society (SCI - Section CSB) (2008)
Satyanarayana U
Biochemistry (2014)
Marjorie Catala et al.
Bio-protocol, 10(12), e3646-e3646 (2021-03-05)
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In addition, functions of tRNAs are often modulated
Maria Anna Bauer et al.
Cell cycle (Georgetown, Tex.), 12(2), 346-352 (2012-12-21)
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging. Like other polyamines, spermidine is also indispensable for successful reproduction at several stages. However, a direct influence on the actual fertilization process, i.e.

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