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Merck
CN

03716

(±)-Lisofylline

analytical standard

Synonym(s):

Lisofylline, (±)-1-(5-Hydroxyhexyl)-3,7-dimethylxanthine, 5-Hydroxy pentoxifylline, Penthydroxyfylline

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About This Item

Empirical Formula (Hill Notation):
C13H20N4O3
CAS Number:
6493-06-7
Molecular Weight:
280.32
NACRES:
NA.24
PubChem Substance ID:
329747785
UNSPSC Code:
41116107
MDL number:
MFCD00871850

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InChI

1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3

SMILES string

O=C1N(CCCCC(O)C)C(N(C)C2=C1N(C)C=N2)=O

InChI key

NSMXQKNUPPXBRG-UHFFFAOYSA-N

grade

analytical standard

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

Quality Level

100

Related Categories

General description

Lisofylline (LSF) is a synthetically modified methylxanthine which is known to exhibit various therapeutic properties. It is a potent anti-inflammatory agent and an antioxidant with the ability to suppress oxygen radical production. LSF is used for treating acute lung injury and also has a role in the early treatment of diabetes.

Application

Lisofylline may be used as an analytical reference standard for the determination of the analyte in rat plasma by various high-performance liquid chromatography (HPLC) based techniques.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCK5315
BCCD3479
BCBV2624

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Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes
Yang Z, et al.
Biochemical and Biophysical Research Communications, 344(3), 1017-1022 (2006)
Lisofylline, a novel antiinflammatory agent, protects pancreatic $\beta$-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism
Chen M, et al.
Endocrinology, 143(6), 2341-2348 (2002)
Lisofylline: a potential lead for the treatment of diabetes
Yang Z, et al.
Biochemical Pharmacology, 69(1), 1-5 (2005)
Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rat
Italiya KS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1061(1), 49-56 (2017)
Validation of a high
Walczak M, et al.
Acta Poloniae Pharmaceutica, 66(3), 215-224 (2009)
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