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Safety Information

00344

Sigma-Aldrich

5-Chloro-2-methyl-4-isothiazolin-3-one solution

~1.2% in H2O

Synonym(s):

5-Chloro-2-methyl-3(2H)-isothiazolone

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About This Item

Empirical Formula (Hill Notation):
C4H4ClNOS
CAS Number:
26172-55-4
Molecular Weight:
149.60
Beilstein:
1210149
MDL number:
MFCD00792550
UNSPSC Code:
12000000
PubChem Substance ID:
24845010

concentration

~1.2% in H2O

impurities

~0.3% 2-methyl-4-isothiazolin-3-one
~1% magnesium chloride
~25% magnesium nitrate

refractive index

n20/D 1.378

mp

200-230 °C

SMILES string

CN1SC(Cl)=CC1=O

InChI

1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3

InChI key

DHNRXBZYEKSXIM-UHFFFAOYSA-N

related product

Product No.
Description
Pricing

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H314,H317,H412

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Sang S Lee et al.
The Journal of dermatology, 39(8), 677-681 (2012-05-03)
As many new cosmetic products are introduced into the market, attention must be given to contact dermatitis, which is commonly caused by cosmetics. We investigate the prevalence of preservative allergy in 584 patients with suspected cosmetic contact dermatitis at 11
Britta Wareing et al.
ALTEX, 37(4), 639-651 (2020-06-11)
While the skin sensitization hazard of substances can be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA wherein
Michael D Lundov et al.
Contact dermatitis, 63(3), 164-167 (2010-08-10)
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial
Wolfgang Uter et al.
Contact dermatitis, 67(3), 125-129 (2012-05-09)
The preservative methylchloroisothiazolinone (MCI)/methylisothiazo- linone (MI) is an important allergen, and has thus been subject to regulation in some areas of exposure, mainly in cosmetics. To examine whether a decline in sensitization prevalence and intensity of elicitation (by the patch
Johannes Geier et al.
Contact dermatitis, 67(6), 334-341 (2012-09-22)
The frequency of sensitization to methylchloroisothiazolinone (MCI)/ methylisothiazolinone (MI) observed in the Information Network of Departments of Dermatology (IVDK) was constantly around 2.1% from 1998 to 2009. After that, it increased to 3.9% in 2011, paralleled by an increase in
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