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NADP-RO

Roche

NADP

Disodium salt

Synonym(s):

β-Nicotinamide adenine dinucleotide phosphate disodium salt, β-NADH phosphate disodium salt, β-NADP-Na2, Triphosphopyridine nucleotide disodium salt

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About This Item

Empirical Formula (Hill Notation):
C21H26N7Na2O17P3
CAS Number:
24292-60-2
Molecular Weight:
787.37
MDL number:
MFCD00065390
UNSPSC Code:
12352302
PubChem Substance ID:
329818702

Quality Level

100

Assay

≥97%

form

powder

mol wt

Mr 743.4
Mr 787.4

packaging

pkg of 1 g (10128058001)
pkg of 100 mg (10128031001)
pkg of 5 g (10240354001)
pkg of 500 mg (10128040001)

manufacturer/tradename

Roche

pH

4.0 ± 1.0(10mg/mL)

λmax

260 nm

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[Na+].[Na+].NC(=O)c1ccc[n+](c1)C2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](OP(O)([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI

1S/C21H28N7O17P3.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);;/q;2*+1/p-2/t10-,11-,13-,14-,15-,16-,20?,21-;;/m1../s1

InChI key

WSDDJLMGYRLUKR-FHQWUTKFSA-L

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General description

Nicotinamide adenine dinucleotide phosphate (NADP) and NADPH form a redox pair. The NADPH/NADP ratio regulates the intracellular redox potential, thereby influencing metabolic reactions in vivo.

Application

The β-NADH phosphate disodium salt has been used for the quantification of glucose in glycogen. It has also been used for the hexokinase assay.

Preparation Note

Storage conditions (working solution): 2 to 8 °C
10 mg/ml in aqueous solution, contains at least 99% NADP after 4 weeks at 2 to 8 °C

Analysis Note

Absorbance coefficients: 18.0 x 103 [l x mol-1 x cm-1] at 260 nm, 5.9 x 103 [l x mol-1 x cm-1] at 333 nm (CN complex)

Absorbance at 340 nm: Imidazol buffer, 100 mM pH 6.7, NADP 2 mM (= 14.87 mg/10 ml) : A340 approximately 0.100.

Absorbance at 360 nm: Aqueous solution of NADP, 10 mg/ml: A360 approximately 0.200-0.250.

Other Notes

For life science research only. Not for use in diagnostic procedures.

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Malgorzata Adamczyk et al.
Methods in enzymology, 500, 233-257 (2011-09-29)
In vitro enzymatic assays of cell-free extracts offer an opportunity to assess in vivo enzyme concentrations. If performed under conditions that resemble the conditions in vivo, they may also reveal some of the capacities and properties of the same enzymes
Redox modulation of glucose-6-P dehydrogenase in Anacystis nidulans and its 'uncoupling' by phage infection.
C Cséke et al.
FEBS letters, 126(1), 85-88 (1981-04-06)
Jinrui Zhang et al.
Scientific reports, 5, 12846-12846 (2015-08-06)
Eukaryotic metabolism is organised in complex networks of enzyme catalysed reactions which are distributed over different organelles. To quantify the compartmentalised reactions, quantitative measurements of relevant physiological variables in different compartments are needed, especially of cofactors. NADP(H) are critical components
Lin Zhu et al.
American journal of physiology. Endocrinology and metabolism, 306(10), E1188-E1197 (2014-04-03)
The development of insulin resistance in the liver is a key event that drives dyslipidemia and predicts diabetes and cardiovascular risk with obesity. Clinical data show that estrogen signaling in males helps prevent adiposity and insulin resistance, which may be

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