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About This Item
Product Name
CHAPS, 98% (from N), suitable for dialysis, solubility: >50% (Aqueous solutions)
InChI key
UMCMPZBLKLEWAF-RFCNGIAKSA-N
InChI
1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22?,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
SMILES string
C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
description
zwitterionic
assay
98% (from N)
form
crystals
mol wt
micellar avg mol wt 6150
614.88 g/mol (anhydrous basis)
packaging
pkg of 10 g (10810118001)
pkg of 50 g (10810126001)
manufacturer/tradename
Roche
aggregation number
10
technique(s)
dialysis: suitable
CMC
4 mM
6 mM (20-25°C)
transition temp
cloud point >100 °C
solubility
>50% (Aqueous solutions)
absorption
<0.06% at 278 nm in water at 1 % (w/v) (Ease of removal*: ++
Note:
* Arbitrary scale ranges from ++ to −)
storage temp.
2-8°C
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Other Notes
Physical form
Preparation Note
Storage conditions (working solution): Do not store in solution, because precipitation may occur.
Application
Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS′ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
General description
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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