ACOA-RO
Roche
Acetyl-Coenzyme A
85% (Enzymatic and Absorbance), 2% (lithium)
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Synonym(s):
Acetyl-Coenzyme A, acetyl-coa
UNSPSC Code:
12352200
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description
Chemical Formula: C23H35N7O17P3SLi3
Quality Level
Assay
85% (Enzymatic and Absorbance)
form
solid
mol wt
Mr 809.6 (acetyl-CoA)
Mr 827.4 (acetyl-CoA-Li3)
packaging
pkg of 010 mg (10101893001)
pkg of 200 mg (11585371001)
pkg of 050 mg (10101907001)
manufacturer/tradename
Roche
concentration
2% (lithium)
storage temp.
2-8°C
Related Categories
General description
Acetyl-Coenzyme A, trilithium salt
Application
Acetyl-Coenzyme A is used to assay CAT enzyme activity in cell extracts using radioisotopes. CAT enzyme activity in cell extracts catalyzes the transfer of acetyl groups from acetylcoenzyme A to chloramphenicol. A number of assays have been developed to measure CAT activity in cell extracts. Acetyl-Coenzyme A has also been used to determine citrate synthase activity.
Biochem/physiol Actions
Acetyl-Coenzyme A (Ac-CoA) is the end product of glycolysis and takes part in the Ac-CoA pathway, which is a metabolic pathway for carbon compounds. Ac-CoA is important in cholesterol synthesis. It also takes part in fatty acid biosynthesis and catabolism of polyamines like spermine and spermidine. A low level of Ac-CoA leads to a loss in glial cell and neuronal function. Ketone bodies and triglycerides give rise to Ac-CoA on hydrolysis and this indirectly leads to increased histone acetylation.
Preparation Note
Working solution: Optimal solvent: water or aqueous solution with a weak acidic pH (4 to 5).
Storage conditions (working solution): -15 to -25 °C
50 mg/ml in phosphate buffer, pH 7, is stable for 3 weeks at -15 to -25 °C. Unfrozen solutions should be immediately used.
Storage conditions (working solution): -15 to -25 °C
50 mg/ml in phosphate buffer, pH 7, is stable for 3 weeks at -15 to -25 °C. Unfrozen solutions should be immediately used.
Other Notes
For life science research only. Not for use in diagnostic procedures.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Biochemistry null
Jean-Pierre Montmayeur and Johannes le Coutre
Fat Detection-Taste, Texture, and Post Ingestive Effects null
Morten Scheibye-Knudsen et al.
Cell metabolism, 20(5), 840-855 (2014-12-03)
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). Since dietary interventions can alter neurodegenerative processes, Csb(m/m) mice were
Giosalba Burgio et al.
Biochimica et biophysica acta, 1799(10-12), 671-680 (2010-05-25)
The eukaryotic genome is a highly organized nucleoprotein structure comprising of DNA, histones, non-histone proteins, and RNAs, referred to as chromatin. The chromatin exists as a dynamic entity, shuttling between the open and closed forms at specific nuclear regions and
Agnieszka Jankowska-Kulawy et al.
Neurochemistry international, 57(7), 851-856 (2010-09-21)
Several pathologic conditions are known to cause thiamine deficiency, which induce energy shortages in all tissues, due to impairment of pyruvate decarboxylation. Brain is particularly susceptible to these conditions due to its high rate of glucose to pyruvate-driven energy metabolism.
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