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Merck
CN

11685929001

Guanidine thiocyanate

Synonym(s):

Guanidine thiocyanate, Guanidinium rhodanide, Guanidinium thiocyanate

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HSCN
CAS Number:
593-84-0
Molecular Weight:
118.16
Beilstein:
3563461
MDL number:
MFCD00013027
UNSPSC Code:
12352200
PubChem Substance ID:
329749530

Key Documents

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form

solid

mol wt

118.16

packaging

pkg of 500 g

manufacturer/tradename

Roche

mp

120-122 °C (lit.)

absorption

≤0.10 at 300 and 410 nm in water at 6 M

shipped in

ambient

storage temp.

20-25°C

SMILES string

SC#N.NC(N)=N

InChI

1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H

InChI key

ZJYYHGLJYGJLLN-UHFFFAOYSA-N

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General description

Guanidine thiocyanate is chaotropic salts which lyse cells and along with nuclease binding matrix it is also seen to inhibit nuclease activity during extraction of DNA. It works as a strong RNase inhibitor in extraction buffers.

Application

Chaotropic agent and strong denaturant; solubilizes cells.
Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride.
Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride.

Features and Benefits

Absorbance: A300 and A410 ≤0.10 (6 M in H2O) each
Formula: CH5N3 x HSCN

Physical form

Crystals

Other Notes

For life science research only. Not for use in diagnostic procedures.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 Inhalation - Eye Dam. 1 - Skin Corr. 1C

Supplementary Hazards

EUH032,EUH071

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
940198
940194
940189
940184
940175

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Weidong Wu et al.
The Journal of biological chemistry, 278(30), 28258-28263 (2003-05-14)
The tumor suppressor PTEN is a putative negative regulator of the phosphatidylinositol 3-kinase/Akt pathway. Exposure to Zn2+ ions induces Akt activation, suggesting that PTEN may be modulated in this process. Therefore, the effects of Zn2+ on PTEN were studied in

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