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11685929001

Sigma-Aldrich

Guanidine thiocyanate

Synonym(s):

Guanidine thiocyanate, Guanidinium rhodanide, Guanidinium thiocyanate

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HSCN
CAS Number:
593-84-0
Molecular Weight:
118.16
Beilstein:
3563461
MDL number:
MFCD00013027
UNSPSC Code:
12352200
PubChem Substance ID:
329749530

form

solid

mol wt

118.16

packaging

pkg of 500 g

manufacturer/tradename

Roche

mp

120-122 °C (lit.)

absorption

≤0.10 at 300 and 410 nm in water at 6 M

shipped in

ambient

storage temp.

20-25°C

SMILES string

SC#N.NC(N)=N

InChI

1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H

InChI key

ZJYYHGLJYGJLLN-UHFFFAOYSA-N

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General description

Guanidine thiocyanate is chaotropic salts which lyse cells and along with nuclease binding matrix it is also seen to inhibit nuclease activity during extraction of DNA. It works as a strong RNase inhibitor in extraction buffers.

Application

Chaotropic agent and strong denaturant; solubilizes cells.
Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride.
Suitable as denaturing agent for proteins. Guanidine thiocyanate is a stronger denaturant than guanidine hydrochloride.

Specifications

Absorbance: A300 and A410 ≤0.10 (6 M in H2O) each
Formula: CH5N3 x HSCN

Physical form

Crystals

Other Notes

For life science research only. Not for use in diagnostic procedures.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 3 Inhalation - Eye Dam. 1 - Skin Corr. 1C

Supplementary Hazards

EUH032,EUH071

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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