10602370001
Roche
Plasmin, bovine
from bovine plasma
Synonym(s):
Plasmin
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About This Item
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biological source
bovine plasma
form
suspension
specific activity
≥2 units/mg protein (At 25 °C with Chromozym PL as the substrate.)
mol wt
Mr ~85 kDa
packaging
pkg of 1 mL (5 U)
manufacturer/tradename
Roche
optimum pH
8.9
shipped in
wet ice
storage temp.
2-8°C
General description
Plasmin is derived from the proteolytic cleavage of its precursor plasminogen. Human Plasmin is made up of two polypeptide chains. The polypeptide chains are connected via disulfide bridges.
Specificity
Serine endopeptidase that hydrolyzes peptide and ester bonds at the carboxylic side of Lys or Arg; more selective than trypsin.
Application
Plasmin from bovine has been used as a standard for assessing plasmin biosensors and for proteolytic assays.
Biochem/physiol Actions
Plasmin plays an important role in proteolysis and fibrinolysis. It possesses inflammatory activity. Plasmin is also involved in the hydrolysis of peptide bonds following arginine or lysine. It also cleaves hormones like glucagon, thrombopoietin and growth hormones. Plasmin plays a role in cleavage of complement factors like C3 and C5, coagulation factors V and VIII, matrix proteins, growth factors, E-cadherins and metalloproteinase.
Physical form
Suspension in 3.2 M ammonium sulfate solution
Other Notes
For life science research only. Not for use in diagnostic procedures.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
does not flash
Flash Point(C)
does not flash
Regulatory Information
动植物源性产品
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Plasmin as a proinflammatory cell activator
Syrovets T, et al.
Journal of Leukocyte Biology, 92(3), 509-519 (2012)
Primary structure of the B-chain of human plasmin
WIMAN B.
European Journal of Biochemistry, 76(1), 129-137 (1977)
A rapid and sensitive biosensor for measuring plasmin activity in milk
Dacres H, et al.
Sensors and Actuators B, Chemical, 301, 127141-127141 (2019)
Plasmin-induced proteolysis and the role of apoprotein (a), lysine and synthetic lysine analogs
Rath M and Pauling L
Journal of Orthomolecular Medicine, 7(1), 17-23 (1992)
Chunyue Zhang et al.
Journal of dairy science, 103(1), 179-190 (2019-11-18)
Fat separation is a limiting factor for the shelf life of UHT milk. It may be promoted by the proteolysis of fat surface-adsorbed proteins (FSAP) by proteases that remain active after UHT treatment. The aim of this research was to
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