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10127647001

Roche

Glucose-6-phosphate

mol wt (glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2), pkg of 5 g

Synonym(s):

D-Glucose 6-phosphate disodium salt hydrate, G-6-P-Na2, Robison ester

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About This Item

Empirical Formula (Hill Notation):
C6H11Na2O9P · xH2O
CAS Number:
3671-99-6
Molecular Weight:
304.10 (anhydrous basis)
Beilstein:
5199009
MDL number:
MFCD00150940
UNSPSC Code:
12352302
PubChem Substance ID:
329748950

form

solid

mol wt

(glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2)

packaging

pkg of 5 g

manufacturer/tradename

Roche

shipped in

ambient

SMILES string

O.[Na+].[Na+].OC1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@H]1O

InChI

1S/C6H13O9P.2Na.H2O/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;;;/h2-10H,1H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t2-,3-,4+,5-,6?;;;/m1.../s1

InChI key

UUWJZXLTPORJKW-WYFATIGWSA-L

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General description

Disodium salt

Application

Substrate for glucose-6-phosphatase.

Biochem/physiol Actions

In mammals, glucose-6-phosphate (G6P) is formed by a kinase acting on glucose. It plays several roles and has its fate determined accordingly. It can get converted back to glucose by a phosphatase enzyme. It can pass into glycogen, or enter into the energy-yielding Embden-Meyerhof path or into the 6-phosphogluconate pathway. Increased levels of blood glucose result in elevated levels of glucose 6-phosphate in liver, skeletal muscle, and adipose tissue. This elevated intracellular level of G6P activates glycogen synthase. G6P may also be involved in the negative regulation of phosphorylation of glycogen synthase via cyclic AMP-stimulated protein kinase.

Components

77% glucose-6-P (enzymatic), 13% sodium, 8% water

Quality

Contaminants: <0.2% glucose (enzymatic)

Formula variant

C6H11O9PNa2

Other Notes

For life science research only. Not for use in diagnostic procedures.

WGK

WGK 1

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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THE ROLE OF GLUCOSE 6-PHOSPHATE IN THE REGULATION OF GLUCOSE METABOLISM IN HUMAN ERYTHROCYTES.
I A ROSE et al.
The Journal of biological chemistry, 239, 12-17 (1964-01-01)
C Villar-Palasí et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 11(7), 544-558 (1997-06-01)
Elevated blood glucose concentrations result in increased intracellular levels of glucose 6-phosphate in liver, skeletal muscle, and adipose tissue. In liver, blood glucose concentrations are the main factor in control of the synthesis of glycogen; insulin has only a potentiating

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