ST1203
Anti-PGC-1α Mouse mAb (1F3.9)
liquid, clone 1F3.9, Calbiochem®
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UNSPSC Code:
12352203
NACRES:
NA.43
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
1F3.9, monoclonal
form
liquid
does not contain
preservative
species reactivity
human, rat, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG
shipped in
wet ice
storage temp.
−70°C
target post-translational modification
unmodified
Gene Information
human ... PPARGC1A(10891)
General description
Protein G purified mouse monoclonal antibody. Recognizes the ~113 kDa PGC-1α protein.
Recognizes the ~113 kDa PGC-1α protein in COS cells.
This Anti-PGC-1α Mouse mAb (1F3.9) is validated for use in Immunoblotting, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation for the detection of PGC-1α.
Immunogen
A recombinant protein consisting of amino acids 1-120 of mouse PGC-1α
Application
Immunoblotting (1 g/ml)
Immunocytochemistry (5-10 g/ml)
Immunohistochemistry (5-10 g/ml)
Immunoprecipitation (1:100)
Warning
Toxicity: Regulatory Review (Z)
Physical form
In 50 mM PBS
Analysis Note
Positive Control
Brown adipose tissue from mice exposed to cold
Brown adipose tissue from mice exposed to cold
Other Notes
Chang, J.S., et al. 2010. J. Biol. Chem.285, 18039.
Zhang, Y. et al. 2009. J. Biol. Chem.284, 32813.
Lai, L., et al. 2008. Genes Dev.14, 1948.
Rodgers, J.T., et al. 2008. FEBS Lett.582, 46.
Mazzucotelli, A., et al. 2007. Diabetes10, 2467.
Nemoto, S., et al. 2005. J. Biol. Chem.16, 16456.
Zhang, Y. et al. 2009. J. Biol. Chem.284, 32813.
Lai, L., et al. 2008. Genes Dev.14, 1948.
Rodgers, J.T., et al. 2008. FEBS Lett.582, 46.
Mazzucotelli, A., et al. 2007. Diabetes10, 2467.
Nemoto, S., et al. 2005. J. Biol. Chem.16, 16456.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
nwg
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Seong-Hoon Yun et al.
Anticancer research, 40(2), 653-664 (2020-02-06)
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a master regulator of mitochondrial biogenesis and metabolism. We investigated the effect of PGC-1α knockdown in the human colorectal cancer cell line SW620, which highly expresses PGC-1α. We established the PGC-1α shRNA-silenced
Dorothy E Vatner et al.
Aging cell, 17(4), e12751-e12751 (2018-04-15)
Disruption of the regulator for G protein signaling 14 (RGS14) knockout (KO) in mice extends their lifespan and has multiple beneficial effects related to healthful aging, that is, protection from obesity, as reflected by reduced white adipose tissue, protection against
Althea N Waldhart et al.
Cell reports, 36(5), 109488-109488 (2021-08-05)
Hyperglycemia affects over 400 million individuals worldwide. The detrimental health effects are well studied at the tissue level, but the in vivo effects at the organelle level are poorly understood. To establish such an in vivo model, we used mice lacking TXNIP
Sajedah M Hindi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(3), 1398-1411 (2013-12-12)
Skeletal muscle wasting attributed to inactivity has significant adverse functional consequences. Accumulating evidence suggests that peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and TNF-like weak inducer of apoptosis (TWEAK)-Fn14 system are key regulators of skeletal muscle mass in various catabolic
Kin H Lau et al.
iScience, 26(1), 105848-105848 (2023-01-11)
Brown adipose tissue (BAT) has the ability to burn calories as heat. Utilizing BAT thermogenesis is thus an attractive way to combat obesity. However, the transcriptional network resulting in the lipid synthesis to oxidation shift during thermogenesis is not completely
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