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SKINMAG-50K

Millipore

MILLIPLEX® Human Skin Magnetic Bead Panel - Immune Response Multiplex Assay

The analytes available for this multiplex kit are: Cortisol, Fibronectin, Involucrin, Keratin-6, Keratin-1,10, HSA.

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000

species reactivity

human

manufacturer/tradename

Milliplex®

assay range

accuracy: 96-107%
sensitivity: 0.25 ng/mL
(Involucrin)
sensitivity: 0.85 ng/mL
(Cortisol)
sensitivity: 2.05 ng/mL
(HSA)
standard curve range: 0.055-40 ng/mL
(Involucrin)
standard curve range: 0.55-400 ng/mL
(Cortisol)
standard curve range: 2.74-2000 ng/mL
(HSA)
inter-assay cv: <15%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

General description

Skin is the largest organ in the body, with such diverse functions as mechanical barrier, thermoregulation, vitamin D synthesis, vitamin B folate protection, fluid homeostasis, sensation, and innate immunity. The skin responds to damage by up-regulating repair mechanisms and causing skin hyperproliferation. Consequently, analysis of biochemical components from the stratum corneum (SC) can be used to evaluate skin irritation, SC integrity and structure and inflammatory changes in human skin.

The MILLIPLEX® Human Skin Panel is a 5-plex kit to be used for the simultaneous quantification of any or all of the following analytes in skin, skin tape extract or skin cell
culture samples: cortisol, keratin-6, involucrin, keratin-1,10, and human serum albumin (HSA).

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Immune Response

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Application

  • Analytes: Cortisol, Human Serum Albumin (HSA), Involucrin, Keratin-6, Keratin-1,10
  • Recommended Sample type: Skin, skin tape extract, skin cell culture samples
  • Assay Run Time: One day or Overnight
  • Research Category: Inflammation & Immunology

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Analysis Note

Fibronectin, Keratin-6, and Keratin 1, 10 are lot specific see product insert.

Other Notes

Please contact Technical Service for linearity of dilution.
Sensitivity: Fibronectin, Keratin-6, and Keratin 1, 10 are lot specific see product insert.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Regulatory Information

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Certificates of Analysis (COA)

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Patrick M Kinn et al.
Scientific reports, 5, 10472-10472 (2015-06-04)
In the skin, aging is associated with overall epidermal thinning, decreased barrier function, and gradual deterioration of the epidermal immune response. However, the presence and role of cytokines, chemokines, and biologic analytes (CCBAs) in immunosenescence are not known. Here we

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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