SCT247
BioTracker MultiTASQ G-Quadruplex (G4) Cell Probe
Synonym(s):
G quadruplex probe, G4 ligand, G4 probe, G4 tetrad probe, Live Cell Imaging Probe, click chemistry probe
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
41106514
NACRES:
NA.52
packaging
vial of 1 mg
Quality Level
manufacturer/tradename
Millipore
growth mode
N/A
technique(s)
DNA sequencing: suitable
RNA extraction: suitable
nucleic acid detection: suitable
detection method
fluorometric
shipped in
dry ice
storage temp.
−20°C
Application
G-quadruplexes are four-stranded structures consisting of stacked G tetrads (G4) formed within select guanine-rich nucleic acid sequences. G-quadruplexes are enriched in open chromatin regions but are also present in the nucleolus and cytoplasm. The formation of G4 structures is dynamic and cell-type specific, suggesting interaction with transcription factors and other proteins. G-quadruplexes have therefore attracted acute interest in their possible contribution in transcriptional regulation.
MultiTASQ was designed utilizing the template-assembled synthetic G-quartets (TASQ) concept as biomimetic ligand for G-quadruplexes, demonstrating high specificity for G4. MultiTASQ is water-soluble and exhibits a high degree of intracellular accessibility. MultiTASQ detects ribosomal RNA-G4 associated with perinuclear rough ER regions to a greater degree compared to BG4 antibody. MultiTASQ is an alkynylated probe that allows for background-free detection via click chemistry and is suitable for G4 capture chemi-precipitation and click imaging applications.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
MultiTASQ was designed utilizing the template-assembled synthetic G-quartets (TASQ) concept as biomimetic ligand for G-quadruplexes, demonstrating high specificity for G4. MultiTASQ is water-soluble and exhibits a high degree of intracellular accessibility. MultiTASQ detects ribosomal RNA-G4 associated with perinuclear rough ER regions to a greater degree compared to BG4 antibody. MultiTASQ is an alkynylated probe that allows for background-free detection via click chemistry and is suitable for G4 capture chemi-precipitation and click imaging applications.
References
1. Nat. Chem. 2021, 13(7): 626-633
2. ACS Chem Biol. 2021, 16(5): 905-914
Purity: > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.
Features and Benefits
MultiTASQ detects ribosomal RNA-G4 associated with perinuclear rough ER regions to a greater degree compared to BG4 antibody. MultiTASQ is an alkynylated probe that allows for background-free detection via click chemistry and is suitable for G4 capture chemi-precipitation and click imaging applications. MultiTASQ is compatible with live-cell incubation. The BioTracker MultiTASQ G4 cell probe is a uniquely designed, versatile tool for G4 detection and analysis.
Physical form
Lyophilized. White solid.
Storage and Stability
Store BioTracker BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light
Other Notes
Fluorescent detection of nucleic acid G4 quadruplexes in cells and tissues using click chemistry
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service