BioTracker Orange OH and HClO Dye

Reactive oxygen species (ROS) are important mediators in a variety of biological and pathological events. For example, ROS generated in mitochondria play important roles in the modulation of signal transduction cascades and transcription factors. However, oxidative stress due to excessive generation of ROS is implicated in many human diseases, including acute and chronic inflammatory processes, ischemic stroke, diabetes, sepsis, ischemia-reperfusion injury, atherosclerosis, and neurodegenerative disorders.BioTracker Orange OH and HClO Dye is an orange fluorescent probe to detect hydroxy radical (・OH) or hypochlorous acid (HClO) in live-cell imaging. It can detect -OH and HClO among other reactive oxygen species (O2^-, H₂O₂, NO, ONOO^-). Its nearly red fluorescence spectrum allows multicolor imaging with green (ex. GFP, FITC) and blue (ex. Hoechst 33342) fluorophores. Because of its positive charge, OxiORANGE tends to localize within mitochondria. It has high photostability and is suitable for time-lapse imaging of intracellular hROS generation.Spectral Properties:Absorbance (max): 553mEmission (max): 577nmResearch Category:Live Cell Dye

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