SCC440
SK-MEL-147 Human Melanoma Cell Line
Human
Synonym(s):
Q61R NRAS melanoma cell line, SK-MEL-147, human melanoma cell line, human melanoma cells, metastatic melanoma cell line
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About This Item
UNSPSC Code:
41106514
NACRES:
NA.81
product name
SK-MEL-147 Human Melanoma Cell Line ,
biological source
human
Quality Level
packaging
vial of ≥1X10⁶ vial
manufacturer/tradename
Millipore
technique(s)
cell culture | mammalian: suitable
shipped in
liquid nitrogen
storage temp.
−196°C
General description
SK-MEL-147 is a human metastatic melanoma cell line. It retains a Q61R NRAS point mutation which is associated with a more aggressive phenotype, higher metastasis risk, and poorer prognosis.
Application
- Each vial contains >1X106 viable cells.
- SK-MEL-147 cells are verified to be of human origin and negative for mouse, rat, Chinese hamster, Golden Syrian hamster, and non-human primate interspecies contamination, as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
- Cells tested negative for infectious diseases against a Contamination Clear panel by Charles River Animal Diagnostic Services.
- Cells tested negative for mycoplasma.
Features and Benefits
The SK-MEL-147 cell line expresses PMEL and MelanA proteins, two common melanoma markers. PMEL has been implicated in poor immune cell infiltration, and may be a relevant target for drug therapy due to its limited expression in normal cell phenotypes.
Target description
Melanoma is considered the most dangerous form of skin cancer. It develops in melanocytes, the pigment producing cells of the skin. Melanoma accounts for a very small number of all skin cancers. Even though it accounts for only about 1% of total diagnosed
Storage and Stability
SK-MEL-147 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting cell marker expression and functionality.
Other Notes
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact l
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
高风险级别生物产品-Merck
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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