SCC163
HOG Human Oligodendroglioma Cell Line
HOG human oligodendroglioma cell line is a useful model to study the role of oligodendrocytes in neurodegenerative diseases.
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Synonym(s):
Oligodendroglioma cells
UNSPSC Code:
41106514
eCl@ss:
32011203
NACRES:
NA.81
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biological source
human
technique(s)
cell based assay: suitable
cell culture | mammalian: suitable
Related Categories
General description
HOG is a clonal cell line derived from a surgically removed human oligodendroglioma (HOG) . HOG cells express oligodendrocyte markers including low levels of the 15-kDa form of myelin basic protein (MBP) and high levels of CNPase protein. HOG cells do not express GFAP, a astrocyte marker and were found to have minimal levels of glutamine synthetase activity . HOG cells express neurotransmitter receptors such as A2-adenosine, prostaglandin E1 (PGE1) and beta2-adrenergic receptores (beta-ARs) that activate the adenylate cylase signaling pathway . HOG cells also express muscarinic and histamine receptors that are linked to inositol phosphate signaling pathways .
Cell Line Description
Cancer Cells
Application
Research Category
Neuroscience
Neuroscience
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
Quality
• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, C, and HIV-1 & 2 viruses as assessed by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, C, and HIV-1 & 2 viruses as assessed by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.
• Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
Storage and Stability
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Stefania Braidotti et al.
Biomedicines, 11(11) (2023-11-25)
Oligodendroglioma (OG) is a brain tumor that contributes to <1% of brain tumor diagnoses in the pediatric population. Unfortunately, pediatric OG remains without definitive molecular characteristics to aid in diagnosis, and little is known about the tumor microenvironment. Tumor cells'
George H De Vries et al.
Neurochemical research, 35(12), 1978-2000 (2010-12-04)
The importance and essential functions of glial cells in the nervous system are now beginning to be understood and appreciated. Glial cell lines have been instrumental in the elucidation of many of these properties. In this Overview, the origin and
Yingyue Zhou et al.
Nature medicine, 26(1), 131-142 (2020-01-15)
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD risk, and activation of disease-associated microglia (DAM) is dependent on TREM2 in mouse models of AD.
G R Post et al.
Glia, 5(2), 122-130 (1992-01-01)
A stable cell line derived from a human oligodendroglioma (HOG) was used to study the regulation of muscarinic- and histamine receptor-mediated phosphoinositide hydrolysis. Both carbachol and histamine increased inositol monophosphate (InsP) accumulation in a dose- and time-dependent manner in the
G R Post et al.
Molecular and chemical neuropathology, 16(3), 303-317 (1992-06-01)
A novel clonal cell line derived from a human glioma (HOG) was found to express some oligodendrocyte-specific proteins including a 15-kDa form of myelin basic protein (MBP) and high 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) activity. Expression of the myelin lipids galactosylceramide
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