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RTHYMAG-30K

Millipore

MILLIPLEX® Rat Thyroid Magnetic Bead Panel - Endocrine Multiplex Assay

The analytes available for this multiplex kit are: TSH, T3, T4.

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UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.47

Quality Level

200

species reactivity

rat

manufacturer/tradename

Milliplex®

assay range

sensitivity: 2255 pg/mL
(T4)
sensitivity: 284 pg/mL
(T3)
sensitivity: 38 pg/mL
(TSH)
standard curve range: 41-10,000 pg/mL
(TSH & T3)
standard curve range: 823-200,00 pg/mL
(T4)
inter-assay cv: <15%
intra-assay cv: <10%

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

Related Categories

General description

The synthesis and release of Triiodothyronine (T3) and thyroxine (T4) are regulated by Thyroid-Stimulating Hormone (TSH), which is secreted by the anterior pituitary gland. These thyroid hormones play critical roles in the regulation of energy balance, metabolism of carbohydrates, fatty acids and proteins. Thyroid hormones are critical to the development of the central nervous and skeletal systems. The simultaneous monitoring of all three hormones can be of great value when researching disease models and therapeutic response.

MILLIPLEX® Rat Thyroid Hormone Panel is a 3-plex kit to be used for the simultaneous quantification of any or all of the following analytes in serum, plasma and tissue culture samples: T3 (competitive assay), T4 (competitive assay), and TSH. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Endocrine

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the analytes within the panel.

Application

  • Analytes: T3, T4, TSH
  • NOTE: T3 and T4 are competitive immunoassays
  • Recommended Sample Type: Rat serum, plasma, cell/tissue culture supernatants or lysates
  • Recommended Sample Dilution: 25 μL per well 1:6 diluted serum or plasma; cell/tissue culture samples may require dilution in an appropriate control medium.
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C
  • Research Category: Endocrine
  • Research Category: Metabolism

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Other Notes

Please contact Technical Service for linearity of dilution.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

WGK

WGK 3

Regulatory Information

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The prospective protective effect of selenium nanoparticles against chromium-induced oxidative and cellular damage in rat thyroid.
Hassanin, KM; Abd El-Kawi, SH; Hashem, KS
International journal of nanomedicine null
Giulia Di Dalmazi et al.
Journal of immunology (Baltimore, Md. : 1950), 202(5), 1350-1362 (2019-01-25)
MYMD-1 is a synthetic derivative of tobacco alkaloids, compounds that possess immunoregulatory properties and have been linked to the epidemiological observation that smoking reduces the odds of developing thyroid Abs and hypothyroidism. To assess the effect and mechanism(s) of the
Rauf Latif et al.
Frontiers in endocrinology, 12, 706101-706101 (2021-07-20)
The synergistic activation of transcription factors can lead to thyroid progenitor cell speciation. We have previously shown in vitro that mouse or human stem cells, expressing the transcription factors NKx2-1 and Pax8, can differentiate into thyroid neo-follicular structures (TFS). We
Sangho Yu et al.
eLife, 7 (2018-05-16)
The adipokine leptin acts on the brain to regulate energy balance but specific functions in many brain areas remain poorly understood. Among these, the preoptic area (POA) is well known to regulate core body temperature by controlling brown fat thermogenesis
Sujie Ke et al.
JCI insight, 6(16) (2021-07-09)
Thyroid hormone receptor β (THRB) is posttranslationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupted sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues. The
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