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PC154

Sigma-Aldrich

Anti-Excitatory Amino Acid Transporter (GLT-1) Rabbit pAb

liquid, Calbiochem®

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

100

antibody form

diluted serum

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

rat

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgG

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

Rattus norvegicus ... Slc1A2(29482)

General description

Anti-Excitatory Amino Acid Transporter (GLT-1), rabbit polyclonal recognizes the ~75 kDa and the ~50 kDa forms of GLT-1. It is validated for use in Western blotting and immunoprecipitation.
Rabbit polyclonal antibody supplied as diluted serum. Recognizes the ~75 kDa and the ~50 kDa forms of GLT-1.
Recognizes the ~75 kDa and the ~50 kDa forms of GLT-1.

Immunogen

a synthetic peptide (NGKSADCSVEEEPWKREK) corresponding to amino acids at the C-terminus of rat GLT-1

Warning

Toxicity: Standard Handling (A)

Other Notes

Arriza, J.L., et al. 1997. Proc. Natl. Acad. Sci. USA94, 4155.
Nagao, S., et al. 1997. Neuroscience78, 929.
Rothstein, J.D., et al. 1995. Ann. Neurol.14, 5559.
Arriza, J.L., et al. 1994. J. Neurosci.14, 5559.
Rothstein, J.D., et al. 1993. Proc. Natl. Acad. Sci. USA90, 6591.
Kanai, Y., et al. 1992. Nature360, 467.
Pines, G., et al. 1992. Nature360, 464.
Rothstein, J.D., et al. 1992. N. Engl J. Med.326, 1464.
Storck T., et al. 1992. Proc. Natl. Acad. Sci. USA89, 10955.
This antibody may also cross react nonspecifically with a ~102 kDa protein not believed to be related to GLT-1. This antibody has also been reported to work for immunoprecipitation. Antibody should be titrated for optimal results in individual systems.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christian M Cremer et al.
Epilepsia, 51(8), 1446-1455 (2010-04-14)
The astrocytic enzyme glutamine synthetase (GS) is a key regulator of glutamate and γ-aminobutyric acid (GABA) metabolism in the glutamate/glutamine cycle (GGC). Inhibition of GS results in changes of neurotransmitter release and recycling. However, little is known about the influence

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