Natrix^® Q Pilot

Strong anion exchange chromatography membrane design to purify biomolecules with a high density of quaternary amine ligand the enables fast flow rates and high throughput at high loads while maintaining excellent impurity reduction

With a revolutionary three-dimensional macroporous hydrogel structure that provides a high density of binding sites and rapid mass transfer, Natrix^®(Q)chromatography membranes deliver binding capacity that exceeds resin-based columns with fast flow rates typical of traditional membrane adsorbers.This combination of performance and speed in a single-use, plug-and-play device format enables low-risk, scalable solutions for efficient biomolecule purification.

Natrix^®(Q)chromatography membrane is a high productivity strong anion exchange membrane designed for biomolecule purification. The unique Natrix^®(Q)chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium^™(Q) binding groups that are directly polymerized within the an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates (seconds of residence time) with impressive throughput to extremely high loads while maintaining excellent impurity reduction across a wide range of buffer conditions. The Natrix^®(Q)chromatography membrane design delivers improvements in productivity, flexibility, and process robustness and economics for any bioprocess design. The Natrix^®(Q) Pilot is an intermediate scale device, intended to verify and adjust operating parameters. The Pilot may be used for small-scale clinical and commercial manufacturing.
mAb nominal polishing capacity: 150 g

Membrane configuration: Pleated

1 device per package

Natrix^® Q membrane adsorber provides users with:

• High density of quaternary amine binding sites enabling rapid mass transfer
• High binding capacity even at fast flow rates
• Combination of performance and speed in, single use, plug-and-play device format enables low risk, scalable solutions for efficient biomolecule purification.

Double bagged

NACONNECT is a trademark of Merck KGaA, Darmstadt, Germany

NATRIFLO is a trademark of Merck KGaA, Darmstadt, Germany

NATRIX is a registered trademark of Merck KGaA, Darmstadt, Germany