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MX0SP027H1

Millipore

Millistak+® Pod Depth Filter

X0SP, filtration area 0.027 m2, hydrophilic

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Synonym(s):
Millistak+ Pro Pod Depth Filter, X0SP media series, 0.027 m 2 surface area, 1/4 in. Hose Barb connection
UNSPSC Code:
23151806
eCl@ss:
32031690

material

acrylic
polypropylene
silica filter aid

Quality Level

400

description

Secondary clarification of bioreactor harvests, post centrate harvest

feature

hydrophilic

manufacturer/tradename

Millistak+®

parameter

2.1 bar max. differential pressure (30 psid) at 25 °C (Forward)
30 psid max. differential pressure (2.1 bar) at 37 °C (Reverse)
30 psid max. differential pressure (2.1 bar) at 4 °C (Forward)
31 psid max. inlet pressure (2.1 bar) at 25 °C

H

140 mm
5.5 in. (14 cm)

L

8.6 in. (22 cm)

filtration area

0.027 m2

impurities

<0.25 EU/mL bacterial endotoxins (LAL test, Aqueous extraction)

input

sample type liquid

conductivity

19.34-53.2 μS/cm at 25 °C (product water)

filter grade

X0SP

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General description

The Millistak+® Pod Depth Filter is a synthetic depth filter providing a cleaner and more consistent depth filtration media over current diatomaceous earth (DE) and cellulose (CE) based filter offerings. This unit, featured in a Lab Scale Pod format with a X0SP media grade, supports primary and secondary clarification as well as downstream filtration applications.

Application

Secondary clarification of bioreactor harvests, post centrate harvest

Features and Benefits

Synthetic materials of construction

  • Reduce TOC extractables and pre-use flush volume requirements by 50%
  • No beta glucans to interfere with limulous amoebocyte lysate (LAL) testing for bacterial endotoxins

Lot to lot consistency for successful development and implementation of robust clarification processes

Depth filter media formulation & design
  • Provide as much as two times the filtration capacity with equivalent filter retention properties over commercial DE-based benchmarks
  • Improved HCP impurity clearance


Disposable Pod device
  • Flexible, modular format offers scalability from 5 to 12,000 liters or more
  • Robust device format; easy to use and set up

Specifications

Filter Grade: X0SP
Trace metals were measured post pure water flush of 50 L/m2 of surface area and 24-hour static soak in pure water. Values based on average of metals extractibles data from three separate uPod device lots. The analysis was made by ICP-MS. The devices were not autoclaved.

Preparation Note

Sterilization Method
1 autoclave cycle of 60 min @ 123 ºC, filtration performance may be impacted. Recommended for post use contamination only.

Analysis Note

Product Water Conductivity at 25°C: post autoclave (1 cycle of 60 minutes at 123 °C) and pure water flush of 10 liters per ft2 (100 L/m2) of media surface area

Legal Information

MILLISTAK+ is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Successfully Navigate the Regulatory Landscape for Chemicals and Single-Use Consumables

This page summarizes key considerations related to regulatory expectations for biomanufacturing including chemicals and polymeric materials. For chemicals, topics include nitrosamines and elemental impurities, and for polymeric materials such as filters and single-use assemblies, the focus is qualification and extractable and leachable testing.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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