MSCRMAG-42K
MILLIPLEX® Mouse Soluble Cytokine Receptor Magnetic Bead Panel - Immunology Multiplex Assay
Simultaneously analyze multiple cytokine and chemokine biomarkers with Bead-Based Multiplex Assays using the Luminex technology, in mouse serum, plasma and cell culture samples.
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About This Item
UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.84
Quality Level
species reactivity
mouse
manufacturer/tradename
Milliplex®
assay range
accuracy: 89-98%
standard curve range: 12.2-50,000 pg/mL
(sIL-1RI, sIL-1RII, sIL-2Rα, sIL-4R, sTNFRII)
standard curve range: 24.4-100,000 pg/mL
(sCD30, sgp130, sIL-6R, sRAGE, sVEGFR1, sVEGFR2, sVEGFR3)
standard curve range: 4.9-20,000 pg/mL
(sTNFRI)
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex xMAP)
shipped in
wet ice
Related Categories
General description
Cytokine receptors constitute an integral part of the cytokine biology. Like cytokines, cytokine receptors are involved in normal physiological and pathological processes of almost all disease states. Soluble cytokine receptors naturally arise from genes encoding membrane-bound receptors or are direct derivatives of the receptors themselves. The discovery that soluble cytokine receptors are involved in regulating excessive inflammatory responses and modulating immune events has stimulated significant research interest in their potential role as immunotherapeutic agents. Many of these soluble cytokine receptors have the ability to inhibit the binding and biological activity of their cytokine ligands, making them very specific cytokine antagonists.
The MILLIPLEX® Mouse Soluble Cytokine Receptor Panel contains 13 metastasis biomarkers that have also been identified in a variety of therapeutic areas. Coupled with the Luminex® xMAP® platform in bead format, this panel enables researchers to focus on discovery with the advantage of simultaneous quantitative multiplex detection leading to speed and sensitivity.
Panel Type: Cytokines/Chemokines
The MILLIPLEX® Mouse Soluble Cytokine Receptor Panel contains 13 metastasis biomarkers that have also been identified in a variety of therapeutic areas. Coupled with the Luminex® xMAP® platform in bead format, this panel enables researchers to focus on discovery with the advantage of simultaneous quantitative multiplex detection leading to speed and sensitivity.
Panel Type: Cytokines/Chemokines
Application
- Analytes: sCD30 (sTNFRSF8), sgp130, sIL-1RI (sCD121a), sIL-1RII (sCD121b), sIL-2Rα (sCD25), sIL-4R (sCD124), sIL-6R (sCD126), sRAGE, sTNFRI (sTNFRSF1A), sTNFRII (sTNFRSF1B), sVEGFR1 (sFlt-1), sVEGFR2 (sFlk-1), sVEGFR3 (sFlt-4)
- Recommended Sample type: serum, plasma and cell culture
- Recommended Sample dilution: 1:5 diluted serum and plasma
- Assay Run Time: Overnight
- Research Category: Inflammation & Immunology
Features and Benefits
Design your multiplex kit by choosing available analytes within this panel.
Packaging
Everything you need in a single kit.
Other Notes
Please contact Technical Service for linearity of dilution.
Sensitivity: Refer to kit protocol for sensitivities of individual biomarkers.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
Regulatory Information
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Damien Restagno et al.
PloS one, 11(8), e0162109-e0162109 (2016-08-31)
Sepsis is characterized by pro- and anti-inflammatory responses following infection. While inflammation is responsible for widespread organ damage, anti-inflammatory mediators lead to immunoparalysis increasing susceptibility to secondary infections (nosocomial pneumonia). We aimed to investigate the impact of bacterial load on
Susana Rodriguez et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 320(1), R19-R35 (2020-10-22)
C1q/TNF-related protein 1 (CTRP1) is an endocrine factor with metabolic, cardiovascular, and renal functions. We previously showed that aged Ctrp1-knockout (KO) mice fed a control low-fat diet develop renal hypertrophy and dysfunction. Since aging and obesity adversely affect various organ
Susana Rodriguez et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2657-2676 (2020-01-08)
Local and systemic factors that influence renal structure and function in aging are not well understood. The secretory protein C1q/TNF-related protein 1 (CTRP1) regulates systemic metabolism and cardiovascular function. We provide evidence here that CTRP1 also modulates renal physiology in
Katherine Young Bezold Lamm et al.
eLife, 7 (2018-01-09)
Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin 2
Saida Breuer et al.
Nutrients, 13(11) (2021-11-28)
Maternal obesity greatly affects next generations, elevating obesity risk in the offspring through perinatal programming and flawed maternal and newborn nutrition. The exact underlying mechanisms are poorly understood. Interleukin-6 (IL-6) mediates its effects through a membrane-bound receptor or by trans-signaling
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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