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Millipore

Millistak+® HC Pro Pod Depth Filter

D0SP, filtration area 0.77 m2, hydrophilic

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Synonym(s):
Millistak+ HC Pro Pod Depth Filter, D0SP media series, 0.77 m 2 surface area
UNSPSC Code:
23151806
eCl@ss:
32031690

material

acrylic
polypropylene
silica filter aid

Quality Level

400

description

Primary clarification directly out of the bioreactor

product line

EMPROVE® Filter

feature

hydrophilic

manufacturer/tradename

Millistak+®

parameter

30 psid max. differential pressure (2.1 bar) at 25 °C (Reverse)
30 psid max. differential pressure (2.1 bar) at 80 °C (Forward)
50 psid max. inlet pressure (3.5 bar) at 80 °C

H

12.5 in. (32 cm)
317 mm

L

24.2 in. (62 cm)

depth

6.4 in. (16.3 cm)

filtration area

0.77 m2

impurities

<0.25 EU/mL bacterial endotoxins (LAL test, Aqueous extraction)

input

sample type liquid

conductivity

18.9-41.5 μS/cm at 25 °C (product water)

filter grade

D0SP

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General description

The Millistak+® HC Pro Pod Depth Filter (high capacity synthetic media) is a synthetic depth filter providing a cleaner and more consistent depth filtration media over current diatomaceous earth (DE) and cellulose (CE) based filter offerings. This unit, featured in a Process Scale Pod format with a D0SP media grade, supports primary and secondary clarification as well as downstream filtration applications.

Application

Primary clarification directly out of the bioreactor

Features and Benefits

Synthetic materials of construction

  • Reduce TOC extractables and pre-use flush volume requirements by 50%
  • No beta glucans to interfere with limulous amoebocyte lysate (LAL) testing for bacterial endotoxins

Lot to lot consistency for successful development and implementation of robust clarification processes

Depth filter media formulation & design
  • Provide as much as two times the filtration capacity with equivalent filter retention properties over commercial DE-based benchmarks
  • Improved HCP impurity clearance


Disposable Pod device
  • Flexible, modular format offers scalability from 5 to 12,000 liters or more
  • Robust device format; easy to use and set up

Specifications

Filter Grade: D0SP
Trace metals were measured post pure water flush of 50 L/m2 of surface area and 24-hour static soak in pure water. Values based on average of metals extractibles data from three separate uPod device lots. The analysis was made by ICP-MS. The devices were not autoclaved.

Preparation Note

Sterilization Method
Integrity is maintained after 1 autoclave cycle of 60 min @ 123 ºC. Filtration performance may be impacted post autoclave. Recommended for post use decontamination only.

Analysis Note

Product Water Conductivity at 25°C: after a pure water flush 50 L/m2 (5 liter per ft2) of media surface area (300 LMH, 10 min). At the end of the flush, a sample was pulled for conductivity measurement. Devices were not autoclaved.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
MILLISTAK+ is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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