MATFLAGELLIN
NEP Control Flagellin- PyroMAT® System MAT
Non-endotoxin pyrogen control of flagellin for use in monocyte activation test
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Synonym(s):
NEP, NEP Control
UNSPSC Code:
41116130
eCl@ss:
32160606
NACRES:
NA.24
Recommended Products
Assay
≥95% (SDS-PAGE)
Quality Level
usage
sufficient for 10 tests
feature
Non-endotoxin pyrogen control of flagellin for use in monocyte activation test
manufacturer/tradename
PyroMAT®
application(s)
pharmaceutical
pyrogen testing
compatibility
configured for PyroDetect System
configured for PyroMAT® System
shipped in
cooler
storage temp.
−20°C
suitability
pyrogenic bacteria
Related Categories
General description
The PyroMAT® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs)is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA.
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).
NEP control flagellin is a preparation of flagellin from Salmonella typhimurium and supplied in a lyophilized form. Flagellin is a non-endotoxin pyrogen (NEP) that activates the TLR5 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).
Specificity
TLR-5 agonist
Application
NEP control of flagellin can be used as a positive control with the PyroMAT® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.
Features and Benefits
Endotoxin-free product at concentration of use in MAT Purity: ≥ 95% (SDS-PAGE)
Storage and Stability
Store unopened vials at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Shelf life of aliquots can be found on the technical datasheet
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Shelf life of aliquots can be found on the technical datasheet
Legal Information
PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany
also commonly purchased with this product
control
Product No.
Description
Pricing
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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