MABS330
Anti-SFRP2 Antibody, clone 8H1
clone 8H1, from rat
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Synonym(s):
Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rat
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
8H1, monoclonal
species reactivity
mouse, horse
species reactivity (predicted by homology)
equine (based on 100% sequence homology), human (immunogen homology)
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SFRP2(6423)
General description
Secreted frizzled-related proteins (SFRPs) may play a critical role in carcinogenesis by inhibiting the Wnt/beta-catenin signaling pathway. Secreted frizzled-related protein 2 (SFRP2) may be useful to further investigate mammary tumorigenesis as its expression increases with tumor progression in canine mammary gland tumors. SFRP2 in mouse embryos has been found to cause severe shortening of the thoracic region. Studies have shown that this protein is the essential stem cell paracrine factor that is thought to regulate myocardial survival and repair damage in the aftermath of an ischemic injury.
Immunogen
Recombinant protein corresponding to human SFRP2.
Application
Detect SFRP using this rat monoclonal antibody, Anti-SFRP2 Antibody, clone 8H1 validated for use in western blotting & IHC.
Research Category
Signaling
Signaling
Research Sub Category
Developmental Signaling
Developmental Signaling
Western Blotting Analysis: A representative lot from an independent laboratory detected SFRP2 in RMG cell lysate and in ERU retinal tissue lysate (Hauck, S. M., et al. (2012). Journal of Proteomics. 75:4545-4554).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected SFRP2 in equine retinal tissue (Hauck, S. M., et al. (2012). Journal of Proteomics. 75:4545-4554).
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected SFRP2 in equine retinal tissue (Hauck, S. M., et al. (2012). Journal of Proteomics. 75:4545-4554).
Quality
Evaluated by Western Blotting in mouse eye tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected SFRP2 in 10 µg of mouse eye tissue lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected SFRP2 in 10 µg of mouse eye tissue lysate.
Target description
~ 33 kDa observed
Physical form
Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse eye tissue lysate
Mouse eye tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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