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Merck
CN

MABN2522

Anti-α-Synuclein (SNCA) Antibody

mouse monoclonal, Syn506

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Species reactivity:
human,
Clone:
Syn506, monoclonal
Application:
ELISA, ICC, IHC, WB
Citations:
-

Key Documents

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Product Name

Anti-alpha-synuclein Antibody, clone Syn506,

species reactivity

human,

antibody form

purified antibody

clone

Syn506, monoclonal

purified by

using protein G

concentration

(Please refer to lot specific datasheet.)

technique(s)

ELISA: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

isotype

IgG1κ

UniProt accession no.

P37840

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General description

14.46 kDa calculated
Recombinant human alpha-synuclein oxidized/nitrated in vitro with peroxynitrite.

Application

ELISA Analysis: A representative lot detected alpha synuclein in ELISA applications (Waxman, E.A., et. al. (2008). Acta Neuropathol. 116(1):37-46).

Immunohistochemistry (Paraffin) Analysis: A representative lot detected alpha synuclein in Immunohistochemistry applications (Waxman, E.A., et. al. (2008). Acta Neuropathol. 116(1):37-46; Sorrentino, Z.A., et. al. (2017). Mol Neurodegener. 12(1):40; Peng, C., et. al. (2018). Nature. 557(7706):558-563).

Western Blotting Analysis: A representative lot detected alpha synuclein in Western Blotting applications (Waxman, E.A., et. al. (2008). Acta Neuropathol. 116(1):37-46).

Immunocytochemistry Analysis: A representative lot detected alpha synuclein in Immunocytochemistry applications (Waxman, E.A., et. al. (2008). Acta Neuropathol. 116(1):37-46).

Biochem/physiol Actions

Clone Syn506 is a mouse monoclonal antibody that detects misfolded alpha-synuclein. It targets an epitope within 20 amino acids from the N-terminal region.

Physical form

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Immunohistochemistry (Paraffin) in human Parkinson′s diseased brain tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected alpha synuclein in human Parkinson′s diseased brain tissue sections.

Other Notes

Human, Mouse.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Regulatory Information

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