MABF941
Anti-Myeloperoxidase Antibody, clone CLB-MPO-1/1,7.17, FITC conjugate
clone CLB-MPO-1/1,7.17, from mouse, FITC conjugate
Sign Into View Organizational & Contract Pricing
All Photos(1)
Myeloperoxidase
Recommended Products
biological source
mouse
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
CLB-MPO-1/1,7.17, monoclonal
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... MPO(4353)
General description
Myeloperoxidase (EC 1.11.2.2; UniProt P05164) is encoded by the MPO gene (Gene ID 4353) in human. Myeloperoxidase/MPO is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a 745 a.a. single chain precursor with a signal peptide sequence (a.a. 1-48), myeloperoxidase is subsequently cleaved into a light chain (a.a.165-278) and a heavy chain (a.a. 279-745). The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. MPO catalyzes hydrogen peroxide-dependent oxidations and the formation of hypochlorous acid that is central to the microbicidal activity of neutrophils.
Specificity
This monoclonal antibody reacts with majority cell types of the myeloid lineage, including myeloblasts, neutrophils, and monocytes. It does not react with human lymphocytes, thrombocytes, or erythrocytes. 96% of all acute myelogenous leukemias (AMLs) are found positive, 100% of all acute lymphoblastic leukemias (ALLs) are found negative when stained with this monoclonal antibody.
Immunogen
Purified human MPO.
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
This Anti-Myeloperoxidase Antibody, clone CLB-MPO-1/1,7.17, FITC conjugate is validated for use in Flow Cytometry for the detection of Myeloperoxidase.
Quality
Evaluated by Flow Cytometry in human PBMCs.
Flow Cytometry Analysis: 0.01 mL of this antibody detected Myeloperoxidase in human peripheral blood monocytes (PBMCs).
Flow Cytometry Analysis: 0.01 mL of this antibody detected Myeloperoxidase in human peripheral blood monocytes (PBMCs).
Target description
~73/83/87 kDa calculated
Physical form
Purified by Ion-Exchange Chromatography
Purified mouse conjugate IgG2aκ monoclonal antibody in buffer containing 20mM Tris, 150mM NaCl, pH8.0 with 1% BSA (w/v), and 0.1% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service