MABF384
Anti-CD127 (IL-7Ra) Antibody (mouse), clone A7R34
clone A7R34, 0.5 mg/mL, from rat
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Synonym(s):
Interleukin-17 receptor A, IL-17 receptor A, IL-17RA, CD217
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source
rat
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
A7R34, monoclonal
species reactivity
mouse
concentration
0.5 mg/mL
technique(s)
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG2aκ
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Il7R(16197)
Related Categories
General description
The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).
Application
This Rat Monoclonal Antibody Anti-CD127 (IL-7Ra) (mouse), clone A7R34, Cat. No. MABF384 is validated for use in IP, IHC, Immunofluorescence and Flow Cytometry for the detection of CD127 (IL-7Ra).
Physical form
Format: Purified
WGK
nwg
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Gabrielle L Goldberg et al.
Journal of immunology (Baltimore, Md. : 1950), 184(11), 6014-6024 (2010-05-21)
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