MABF275
Anti-MRP8 Antibody/ABCC11, clone 2
clone 2, from mouse
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Synonym(s):
ATP-binding cassette sub-family C member 11, Multidrug resistance-associated protein 8, MRP-8
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2, monoclonal
species reactivity
human
technique(s)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ABCC11(85320)
General description
MRP8/ABCC11 is an interesting protein important in a wide range of cellular processes from bile acid metabolism to ear wax secretion. MRP8/ABCC11 is involved in the ATP-dependent uptake of lipophilic anions, steroid sulfates and various bile acids and plays roles in cAMP and cGMP metabolism as well. MRP8/ABCC11 is a member of the ABC transporter superfamily of proteins. MRP8/ABCC11 is a membrane bound protein and is widely expressed except in kidney, spleen and colon. MRP8/ABCC11 is also expressed in many cancers including breast cancer where it serves as a conformational marker. Interestingly, earwax is a Mendelian trait and can be wet or dry. The Arg-184 allele of MRP8/ABCC11 gene is responsible for dry ear wax (cerumen).
Immunogen
Recombinant protein corresponding to human MRP8/ABCC11.
Application
This Anti-MRP8 Antibody/ABCC11, clone 2 is validated for use in Western Blotting for the detection of MRP8/ABCC11.
Quality
Evaluated by Western Blotting in SK-BR3 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected MRP8/ABCC11 in 10 µg of SK-BR3 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected MRP8/ABCC11 in 10 µg of SK-BR3 cell lysate.
Target description
~170 kDa observed. The calculated molecular weight of this protein is 154 kDa, it has an isoform at 150 kDa and can run higher due to glycosolation. Uncharacterized bands may be observed in some lysates.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to lot specific datasheet.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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