MABF2128
Anti-Properdin Antibody, clone 6E11A4
clone 6E11A4, from mouse
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Synonym(s):
Complement factor P
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43
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biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6E11A4, monoclonal
species reactivity
baboon, rabbit, canine, human
packaging
antibody small pack of 25 μg
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Gene Information
human ... CFP(5199)
Related Categories
General description
Properdin (UniProt: P27918; also known as Complement factor P) is encoded by the CEP (also known as PFC) gene (Gene ID: 5199) in human. (ABF185: Properdin (UniProt P27918; also known as Complement factor P) is encoded by the CFP (also known as PFC, PFD) gene (Gene ID 5199) in human. Properdin is a plasma glycoprotein and the only known positive regulator of the complement cascade. It binds and stabilizes the alternative pathway (AP) C3 convertase C3bBb and may also serve as a platform to form new C3bBb convertases on cell surface. Properdin-mediated AP activation plays an important role in host defense, and properdin deficiency (PFD) increases the risk for Neisseria meningitidis infection in human. Properdin-deficiency exacerbated disease condition in a murine model of factor H- (fH-) related C3 glomerulopathy, but prevented the development of allergen-induced airway inflammation. Human properdin is produced with a signal peptide sequence (a.a. 1-27), which is removed posttranslationally to yield the mature protein (a.a. 28-469) composed entirely of seven TSP type-1 domains (domain 0 through 6; a.a. 28-462). TSP type-1 domains 0 and 6 bind to each other and mediate multimerization.
Specificity
Clone 6E11A4 specifically detects human properdin.
Application
Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected Properdin in human tonsil tissue sections.
ELISA Analysis: A representative lot detected Properdin in ELISA applications (Blatt, A.Z., et. al. (2016). J Immunol. 196(11):4671-4680).
Inhibition Analysis: A representative lot detected Properdin in Inhibition applications (Blatt, A.Z., et. al. (2016). J Immunol. 196(11):4671-4680).
ELISA Analysis: A representative lot detected Properdin in ELISA applications (Blatt, A.Z., et. al. (2016). J Immunol. 196(11):4671-4680).
Inhibition Analysis: A representative lot detected Properdin in Inhibition applications (Blatt, A.Z., et. al. (2016). J Immunol. 196(11):4671-4680).
This mouse monoclonal Anti-Properdin, clone 6E11A4 Antibody, Cat. No. MABF2128 is tested for use in Western Blotting, ELISA, and Immunohistochemistry (Paraffin), for the detection of Properdin. Inhibits function in Properdin.
Quality
Evaluated by Western Blotting in purified human properdin.
Western Blotting Analysis: 1 µg/mL of this antibody detected Properdin in purified human properdin.
Western Blotting Analysis: 1 µg/mL of this antibody detected Properdin in purified human properdin.
Target description
~51 kDa observed; 51.28 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physical form
Format: Purified
Other Notes
Concentration: Please refer to lot specific datasheet.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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