MABF2091
Anti-CD6 Antibody, clone 34-3
clone 34-3, from rat
Sign Into View Organizational & Contract Pricing
All Photos(1)
T-cell differentiation antigen CD6
Recommended Products
biological source
rat
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
34-3, monoclonal
species reactivity
mouse
packaging
antibody small pack of 25 μg
technique(s)
flow cytometry: suitable
isotype
IgG2bκ
NCBI accession no.
UniProt accession no.
target post-translational modification
unmodified
Gene Information
mouse ... Cd6(12511)
Related Categories
General description
T-cell differentiation antigen CD6 (UniProt: Q61003; also known as CD6) is encoded by the Cd6 gene (Gene ID: 12511) in murine species. CD6 is a single-pass type I membrane protein that is detected at the immunological synapse the contact zone between antigen-presenting dendritic cells and T-cells. It functions as a costimulatory molecule and promotes T-cell activation and proliferation. After T-cell activation, CD6 is hyperphosphorylated on serine and threonine residues and it is also phosphorylated on tyrosine residues in response to stimulation of the TCR complex. CD6 is predominantly expressed in thymus, lymph node, and spleen. It mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. It also contributes to signaling cascades triggered by activation of the TCR/CD3 complex. It functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. It binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. It mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. CD6 is synthesized with a signal peptide (aa 1-16), which is cleaved off to produce a mature form, which has an extracellular domain (aa 17-398), a transmembrane region (aa 399-419), and a long cytoplasmic tail (aa 420-665).
Specificity
Clone 34-3 is a rat monoclonal antibody that detects T-cell differentiation antigen CD6 in murine species.
Immunogen
CD6-transfected NB2 cells
Epitope: extracellular domain
Application
Anti-CD6, clone 34-3, Cat. No. MABF2091, is a rat monoclonal antibody that detecs T-cell differentiation antigen CD6 and has been tested for use in Flow Cytometry.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Quality
Evaluated by Flow Cytometry in mouse splenocytes.
Flow Cytometry Analysis: 1 µg of this antibody detected CD6 in one million mouse splenocytes.
Flow Cytometry Analysis: 1 µg of this antibody detected CD6 in one million mouse splenocytes.
Target description
72.26 kDa calculated.
Physical form
Format: Purified
Protein G purified
Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service